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The protective effect of L-arginine, tadalafil, and their combination in rat testes after ischemia and reperfusion injury
- Publication Year :
- 2017
- Publisher :
- Canadian Urological Association, 2017.
-
Abstract
- Introduction: Nitric oxide (NO) plays an important role in the ischemia and reperfusion process. In this study, we aimed to examine the effect of L-arginine, tadalafil, and their combination for preventionof the ischemia reperfusion injury after testis torsion in rats.Methods: A total of 40 adult, male Sprague-Dawley rats were allocated into five groups. Three hours of left testicular torsion was performed in each group, excluding the control group. While the ischemia reperfusion (I/R) group had no treatment, I/R + Arg group received L-arginine, I/R + Td group received tadalafil and I/R + Arg + Td group received tadalafil and L-arginine 30 minutes before the detorsion. Then the left testis was untwisted for four hours of reperfusion. After bilateral orchiectomy, lipid peroxidation (LPx) and glutathione (GSH) activities were examined in testicular tissue.Spermatogenesis was evaluated with Johnsen’s score.Results: LPx levels of the I/R group were found to be significantly higher than for groups that received drugs for both testes (p
- Subjects :
- 0301 basic medicine
Male
Arginine
Animal tissue
Tadalafil
chemistry.chemical_compound
0302 clinical medicine
Nitric-oxide
Spermatic cordi
Testicular torsion
Urology & nephrology
Original Research
Protection
Lipid
Left Testis
Schemia/reperfusion injury
Glutathione
Reperfusion injury
Damage
Oncology
030220 oncology & carcinogenesis
Experimental testicular torsion
medicine.drug
Adult
medicine.medical_specialty
Urology
Lipid peroxidation
Article
Nitric oxide
03 medical and health sciences
Internal medicine
medicine
Pharmacological approach
Animal model
Animal experiment
Spermatogenesis
Tissue
business.industry
Inhibitors
Testis torsion
Contralateral testis
medicine.disease
Nonhuman
Drug effect
030104 developmental biology
Endocrinology
chemistry
Prepubertal rats
Rat
Reperfusion Injury
Seminiferous Tubules
Testes
business
Controlled study
Orchiectomy
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....01eaa74a9c54fd4ad1b7ef35e59990d1