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Studies on transfer of varicella-zoster-virus specific T-cell immunity from bone marrow donor to recipient
- Source :
- Blood. 75(3)
- Publication Year :
- 1990
-
Abstract
- The transfer of antigen-specific cellular immunity in human bone marrow transplantation (BMT) was studied in 49 donor-recipient pairs, using a varicella-zoster-virus (VZV) specific lymphoproliferative response (LPR) assay. Posttransplant VZV-LPR could be serially measured in 31 long-term surviving recipients. VZV-specific T-cell immunity was detected in the early posttransplant period in 4 of 16 recipients who were, and whose donors were, immune to VZV before BMT, but two of those positive responses diminished in the first 100 days posttransplant. No positive response was detected in the immediate posttransplant period when either only the recipient or the donor was immune to VZV pretransplant. Herpes zoster or chickenpox developed in the recipients depending on a history of pretransplant VZV infection when the VZV-LPR became negative, and recovery from VZV infection was always followed by quick conversion of VZV-LPR. Long-lasting positive VZV-LPR was observed in the two recipients who experienced VZV infection in the immediate pretransplant period and received marrow graft from an immune donor. Our results indicate that a simple or direct transfer of VZV-specific cellular immunity from a marrow donor to a recipient cannot be expected in usual clinical bone marrow transplantation and that there might be a collaboration or recruitment of immune responses involving both donor and recipient that permits the VZV-LPR to remain positive posttransplant.
- Subjects :
- Cellular immunity
Herpesvirus 3, Human
viruses
T-Lymphocytes
Immunology
medicine.disease_cause
Lymphocyte Activation
Biochemistry
Herpes Zoster
Immune system
Immunity
medicine
Humans
Aplastic anemia
Bone Marrow Transplantation
Immunity, Cellular
Chickenpox
integumentary system
business.industry
Varicella zoster virus
virus diseases
Cell Biology
Hematology
biochemical phenomena, metabolism, and nutrition
medicine.disease
Virology
eye diseases
Tissue Donors
medicine.anatomical_structure
Bone marrow
business
Lymphoproliferative response
Subjects
Details
- ISSN :
- 00064971
- Volume :
- 75
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Blood
- Accession number :
- edsair.doi.dedup.....01da851f65342a1de0be3ad12825c102