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Serum selenium, selenoprotein P and glutathione peroxidase 3 as predictors of mortality and recurrence following breast cancer diagnosis: A multicentre cohort study
- Source :
- Redox Biology, Redox Biology, Vol 47, Iss, Pp 102145-(2021)
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- The trace element selenium is of essential importance for the synthesis of a set of redox active proteins. We investigated three complementary serum selenium status biomarkers in relation to overall survival and recurrence following diagnosis of primary invasive breast cancer in a large prospective cohort study. The Sweden Cancerome Analysis Network – Breast Initiative (SCAN-B) is a prospective population-based study including multiple participating hospitals. Main analyses included 1996 patients with a new diagnosis of primary invasive breast cancer, with blood sampling at the time of diagnosis. In sera of the patients, total serum selenium, selenoprotein P (SELENOP), and glutathione peroxidase 3 (GPx3) activity was analysed. All three biomarkers showed a positive correlation (p<br />Graphical abstract Image 1<br />Highlights • Three different serum biomarkers of selenium status are inversely associated with all-cause mortality following breast cancer diagnosis. • Lower serum glutathione peroxidase 3 activity is associated with more recurrences following breast cancer. • Patients in the lowest quintile regarding all three serum biomarkers have a particularly high all-cause mortality.
- Subjects :
- Medicine (General)
medicine.medical_specialty
QH301-705.5
Clinical Biochemistry
Population
Breast Neoplasms
Prognostic factors
Biochemistry
Gastroenterology
Cohort Studies
Selenium
R5-920
Breast cancer
Internal medicine
Selenoprotein P
medicine
Biomarkers, Tumor
Micronutrient
Humans
Prospective Studies
Biology (General)
Mortality
Prospective study
education
Prospective cohort study
education.field_of_study
Glutathione Peroxidase
Proportional hazards model
business.industry
Organic Chemistry
Hazard ratio
medicine.disease
Female
business
Biomarkers
Cohort study
Blood sampling
Research Paper
Subjects
Details
- Language :
- English
- ISSN :
- 22132317
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Redox Biology
- Accession number :
- edsair.doi.dedup.....01cb46b1e8f9ea1d683d564f90ab30c6