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Corneal Vertical and Horizontal Thickness Profiles Generated by UHR-OCT for Suspected and Subclinical Keratoconus Diagnosis
- Source :
- Journal of Refractive Surgery. 37:438-445
- Publication Year :
- 2021
- Publisher :
- SLACK, Inc., 2021.
-
Abstract
- PURPOSE: To verify the diagnostic power of vertical and horizontal thickness profiles of the corneal sublayers generated by ultra-high resolution optical coherence tomography (UHROCT) in subclinical and suspected keratoconus. METHODS: In this cross-sectional study, 25 eyes with confirmed keratoconus, 63 eyes with suspected keratoconus, 15 eyes with subclinical keratoconus, and 42 normal eyes were investigated. Vertical and horizontal thickness profiles of the corneal epithelium, Bowman's layer, and stroma were measured by UHR-OCT. Diagnostic indices included ratios of thickness distribution and multimeric discriminant functions calculated by multiple logistic regression based on them. Receiver operating characteristic curves were used to verify the predictive accuracy by the area under the curve (AUC). RESULTS: Function consisting of two indices (vertical maximum ectasia index of epithelium and horizontal maximum ectasia index of Bowman's layer) performed well to discriminate subclinical keratoconus (AUC = 0.967) and suspected keratoconus (AUC = 0.932) from normal. In addition, when four indices were combined, the diagnostic power for subclinical keratoconus (AUC = 0.984) and suspected keratoconus (AUC = 0.971) was further increased. However, both binary and quaternary functions could not adequately discriminate suspected from subclinical keratoconus. CONCLUSIONS: UHR-OCT–generated thickness indices from the vertical and horizontal thickness profiles of the corneal epithelium and Bowman's layer showed an evident diagnostic efficacy in discriminating suspected and subclinical keratoconus from normal eyes. The early changes in keratoconus might prefer thickness distribution in corneal sublayers rather than corneal thickness or topography. [ J Refract Surg . 2021;37(7):438–445.]
- Subjects :
- Keratoconus
medicine.medical_specialty
genetic structures
Cornea
Optical coherence tomography
Ectasia
Ophthalmology
medicine
Humans
Corneal epithelium
Subclinical infection
medicine.diagnostic_test
Receiver operating characteristic
business.industry
Corneal Topography
medicine.disease
Corneal topography
eye diseases
Cross-Sectional Studies
medicine.anatomical_structure
ROC Curve
Surgery
sense organs
business
Tomography, Optical Coherence
Subjects
Details
- ISSN :
- 1081597X
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- Journal of Refractive Surgery
- Accession number :
- edsair.doi.dedup.....01ca2e47bba77a87dbef45c1dba0c4c3
- Full Text :
- https://doi.org/10.3928/1081597x-20210330-01