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Comparison of Injectable Biphasic Calcium Phosphate and a Bovine Xenograft in Socket Preservation: Qualitative and Quantitative Histologic Study in Humans
- Source :
- International Journal of Molecular Sciences, Volume 23, Issue 5, International Journal of Molecular Sciences; Volume 23; Issue 5; Pages: 2539
- Publication Year :
- 2022
-
Abstract
- This study is the first histologic evaluation of an injectable biphasic calcium phosphate (IBCP) in humans six months after socket preservation according to the principles of guided bone regeneration. After tooth extraction, the alveolar ridge of 21 patients was augmented with IBCP (maxresorb® inject) in the test group, while 20 patients in the control group received a bovine xenograft (BX) (cerabone®). Six months after augmentation, a reentry procedure was performed to collect biopsies of regenerated bone for qualitative and quantitative histologic analysis. A total of 20 biopsies were taken for analysis. Qualitative histologic analysis showed complete integration of the biomaterial and no inflammatory tissue reaction, indicating the biocompatibility of the bone grafts and the surrounding tissue in both groups. Histomorphometric analysis showed comparable results in terms of newly formed bone (IBCP: 26.47 ± 14.71%, BX: 30.47 ± 16.39%) and residual biomaterial (IBCP: 13.1 ± 14.07%, BX: 17.89 ± 11.81%), with no significant difference found across groups (p > 0.05, Mann—Whitney U test). Statistical significance between groups was found in the result of soft tissue percentage (IBCP: 60.43 ± 12.73%, BX: 51.64 ± 14.63%, p = 0.046, Mann—Whitney U test). To conclude, IBCP and BX showed good osteoconductivity and biocompatibility with comparable new bone formation six months after alveolar ridge preservation.
- Subjects :
- BIOMEDICINA I ZDRAVSTVO. Dentalna medicina
biphasic calcium phosphate
qualitative histology
Biocompatible Materials
Catalysis
Inorganic Chemistry
socket preservation
Animals
Humans
BIOMEDICINE AND HEALTHCARE. Dental Medicine
Tooth Socket
Physical and Theoretical Chemistry
xenograft
Molecular Biology
Spectroscopy
Bone Transplantation
Organic Chemistry
guided bone regeneration
tissue engineering
quantitative histology
Alveolar Ridge Augmentation
General Medicine
Computer Science Applications
Heterografts
Cattle
Hydroxyapatites
Subjects
Details
- Language :
- English
- ISSN :
- 14220067
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences, Volume 23, Issue 5, International Journal of Molecular Sciences; Volume 23; Issue 5; Pages: 2539
- Accession number :
- edsair.doi.dedup.....01c4af9789907a2b16f90c9228f2fbd9