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Methotrexate in juvenile rheumatoid arthritis
- Source :
- European Journal of Clinical Pharmacology. 47
- Publication Year :
- 1995
- Publisher :
- Springer Science and Business Media LLC, 1995.
-
Abstract
- Children with juvenile rheumatoid arthritis (JRA) have been reported to require higher doses (per kg body weight) of methotrexate (MTX) than adults with rheumatoid arthritis to control their disease. The purpose of the present study was to characterise the plasma pharmacokinetics of MTX and its major metabolite, 7-hydroxymethotrexate (7-OHMTX) in children, and to compare the results with those previously obtained in adults. Thirteen patients (age 5-16 y) with JRA (median disease duration 5.5 y) were studied after once weekly oral administration of MTX (median 0.21 mg.kg-1). The analytical method was sufficiently sensitive to permit determination of plasma and urinary concentrations of MTX and 7-OHMTX during the entire dose interval in most of the patients. The dose normalized area under the plasma concentration versus time-curve (AUC) of MTX increased with the age of the children and was lower than previously found in adults. The dose normalized AUC of 7-OHMTX was not dependent on age. No correlation was found between the AUCs of MTX and 7-OHMTX. The results suggest that the age-dependence of the pharmacokinetics of MTX might explain the observation that at least some children require higher doses of MTX than adults to obtain a sufficient therapeutic effect.
- Subjects :
- Male
musculoskeletal diseases
medicine.medical_specialty
Adolescent
medicine.drug_class
Biological Availability
Gastroenterology
Antimetabolite
chemistry.chemical_compound
Pharmacokinetics
immune system diseases
Oral administration
Internal medicine
Immunopathology
medicine
Humans
Pharmacology (medical)
Child
skin and connective tissue diseases
Pharmacology
business.industry
Age Factors
General Medicine
medicine.disease
Arthritis, Juvenile
Methotrexate
chemistry
Child, Preschool
Rheumatoid arthritis
Antifolate
Female
business
Juvenile rheumatoid arthritis
Protein Binding
medicine.drug
Subjects
Details
- ISSN :
- 14321041 and 00316970
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- European Journal of Clinical Pharmacology
- Accession number :
- edsair.doi.dedup.....01bcfa1b5cefe48ab99e8f28b82048ce