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β-1,3-glucanase disrupts biofilm formation and increases antifungal susceptibility of Candida albicans DAY185
- Source :
- International Journal of Biological Macromolecules. 108:942-946
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- β-1,3-glucan plays a role in Candida biofilm formation and survival of biofilm-forming Candida to stresses. In this study, we evaluated the antibiofilm activity of β-1,3-glucanase, which can degrade poly-β(1→3)-glucose of Candida albicans biofilms. Biofilm was dispersed by 55.96%. β-1,3-glucanase had no effect on Candida planktonic growth as well as adhesion. β-1,3-glucanase markedly enhanced the antifungal susceptibility of fluconazole and amphotericin B. The examination using confocal laser scanning microscopy and scanning electron microscope confirmed the antibiofilm activity of β-1,3-glucanase. Our findings demonstrate that β-1,3-glucanase may be useful as an antibiofilm agent.
- Subjects :
- 0301 basic medicine
Antifungal
Antifungal Agents
medicine.drug_class
Scanning electron microscope
030106 microbiology
Microbial Sensitivity Tests
Biochemistry
Microbiology
03 medical and health sciences
Drug Resistance, Fungal
Structural Biology
Candida albicans
medicine
Molecular Biology
chemistry.chemical_classification
biology
Biofilm
Glucan 1,3-beta-Glucosidase
General Medicine
Adhesion
Glucanase
biology.organism_classification
Phenotype
030104 developmental biology
Enzyme
chemistry
Biofilms
Fluconazole
medicine.drug
Subjects
Details
- ISSN :
- 01418130
- Volume :
- 108
- Database :
- OpenAIRE
- Journal :
- International Journal of Biological Macromolecules
- Accession number :
- edsair.doi.dedup.....01ae8d06071837a01e2a9756209858a7