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Necessity of Assessing Biological Exposure to Arsenic Species by Two Representative Analytical Methods
- Source :
- Toxics, Volume 9, Issue 6, Pages: 138, Toxics, Vol 9, Iss 138, p 138 (2021)
- Publication Year :
- 2021
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2021.
-
Abstract
- Arsenic (As) exists as highly toxic chemical species. Chronic exposure to its inorganic form can cause multiple organ failure and skin cancer in humans, warranting the need to determine the toxicity of each chemical species. This study evaluated the proportions of exposure to four chemical species of As (cAs), namely arsenite (AsIII), arsenate (AsV), monomethylarsinic acid (MMA), and dimethylarsenic acid (DMA), and it confirmed the necessity of evaluating biological exposure to cAs. Urine samples were collected from 457 subjects residing near 103 abandoned metal mines. Hydride generation atomic absorption spectroscopy (HG-AAS) was performed to measure the combined concentration of four cAs (hAsAAS). High-performance liquid chromatography and inductively coupled plasma-mass spectrometry (HPLC-ICP-MS) were performed to determine the concentrations of the individual cAs and the sum of the four cAs (hAsICP). The proportions of AsV and MMA were relatively higher in the low-hAsICP concentration section. These findings suggest that hAsAAS, which is mainly used for its cost-efficiency, is limited for evaluating exposure. Though hAsAAS was found to exist in a low concentration, highly toxic AsV and MMA could be observed in high concentrations. Therefore, HPLC-ICP-MS is recommended for assessing cAs in environmentally vulnerable areas such as abandoned metal mines.
- Subjects :
- Chronic exposure
010504 meteorology & atmospheric sciences
Health, Toxicology and Mutagenesis
chemistry.chemical_element
Urine
TP1-1185
010501 environmental sciences
Toxicology
01 natural sciences
Article
law.invention
chemistry.chemical_compound
law
biological exposure assessment
inductively coupled plasma mass spectrometry
Inductively coupled plasma mass spectrometry
Arsenic
0105 earth and related environmental sciences
Arsenite
Chemical Health and Safety
Chemistry
Chemical technology
monomethylarsinic acid
dimethylarsenic acid
Arsenate
humanities
arsenite
Environmental chemistry
atomic absorption spectroscopy
Toxicity
embryonic structures
arsenate
Atomic absorption spectroscopy
Subjects
Details
- Language :
- English
- ISSN :
- 23056304
- Database :
- OpenAIRE
- Journal :
- Toxics
- Accession number :
- edsair.doi.dedup.....01ab5e03c85e1914488a17262ef9f762
- Full Text :
- https://doi.org/10.3390/toxics9060138