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High prevalence of iga rheumatoid factor in severe polyarticular-onset juvenile rheumatoid arthritis, but not in systemic-onset or pauciarticular-onset disease
- Source :
- Arthritis & Rheumatism. 33:199-204
- Publication Year :
- 1990
- Publisher :
- Wiley, 1990.
-
Abstract
- The presence of IgA rheumatoid factor (IgA-RF) has been correlated with severe joint disease in adult rheumatoid arthritis (RA), but IgA-RF has not been reported in juvenile rheumatoid arthritis (JRA). In the present study, IgA-RF was assayed by an enzyme-linked immunosorbent assay and was found in the sera of 14 of 24 children (58%) with active polyarticular JRA. The presence of IgA-RF correlated with the degree of functional disability. In contrast, IgA-RF was not found in the sera of systemic-onset disease patients, regardless of the degree of dysfunction. IgA-RF was detected in only 1 patient with pauciarticular disease, despite the fact that several patients in this group had severe disease. The presence of IgA-RF in polyarticular JRA did not correlate with serum IgA levels, but did correlate with the presence and the level of serum IgM-RF. Thus, the presence of IgA-RF appears to be specific for polyarticular JRA, and shows a correlation with severe disease in this group.
- Subjects :
- Adult
Male
musculoskeletal diseases
Adolescent
Immunology
Enzyme-Linked Immunosorbent Assay
Cell Separation
Disease
Immunoglobulin E
Arthritis, Rheumatoid
Immunoglobulin Fab Fragments
Rheumatology
Rheumatoid Factor
Humans
Immunology and Allergy
Rheumatoid factor
Medicine
Pharmacology (medical)
Child
skin and connective tissue diseases
Cells, Cultured
biology
business.industry
medicine.disease
Immunoglobulin A
Immunoglobulin Fc Fragments
El Niño
Child, Preschool
Immunoglobulin G
Rheumatoid arthritis
biology.protein
Female
Polyarthritis
Antibody
business
Juvenile rheumatoid arthritis
Subjects
Details
- ISSN :
- 15290131 and 00043591
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Arthritis & Rheumatism
- Accession number :
- edsair.doi.dedup.....019ee9d78453481e6491711f0828e8bf