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Association between Mediators in the Tear Fluid and the Severity of Keratoconus
- Source :
- Ophthalmic Research. 51:46-51
- Publication Year :
- 2013
- Publisher :
- S. Karger AG, 2013.
-
Abstract
- Purpose: To study the association between different types of mediators in the tear fluid and topographic indices characterizing the severity of keratoconus (KC). Methods: In this study, nonstimulated tear fluid samples were collected from 14 eyes of 11 patients with KC. The following indices were measured by corneal topography: maximum K value, average K value, Klyce/Maeda keratoconus index (KCI), Smolek/Klyce keratoconus severity index, opposite sector index, center/surround index, keratoconus prediction index and standard deviation of corneal power. The concentrations of interleukin (IL)-6, IL-13, CXCL8 (IL-8), chemokine (C-C motif) ligand 5 (CCL5, regulated and normal T cell expressed and secreted), matrix metalloproteinase-9 (MMP-9), MMP-13, tissue inhibitor of metalloproteinase-1, nerve growth factor (NGF) and epidermal growth factor were measured by cytometric bead array technology. Release of mediators was calculated from their concentrations and the volume of tears collected over 2 min. Results: Significant positive associations were found between CCL5, MMP-13 and NGF and several topographic indices. Significant negative correlations were found between IL-6 and KCI. Age-dependent associations were observed between IL-13, CXCL8, CCL5 and MMP-13 and the topographic data. Conclusion: Several correlations were observed between the mediators and the topographic indices, suggesting possible roles in the pathophysiology of KC. Our data indicate that some mediators have different effects on the severity of disease in an age-dependent manner.
- Subjects :
- Adult
Male
medicine.medical_specialty
Keratoconus
genetic structures
macromolecular substances
Klinikai orvostudományok
Severity of Illness Index
Young Adult
Cellular and Molecular Neuroscience
Ophthalmology
Humans
Medicine
Eye Proteins
Tissue Inhibitor of Metalloproteinase-1
business.industry
Corneal Topography
Orvostudományok
General Medicine
Middle Aged
medicine.disease
Matrix Metalloproteinases
eye diseases
Sensory Systems
Tears
Cytokines
Intercellular Signaling Peptides and Proteins
Regression Analysis
Female
sense organs
business
Subjects
Details
- ISSN :
- 14230259 and 00303747
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- Ophthalmic Research
- Accession number :
- edsair.doi.dedup.....01996cd506667ce532aa1705eba1725c