Additional file 4 of Single-cell analysis of a tumor-derived exosome signature correlates with prognosis and immunotherapy response

Additional file 4: Figure S4. Predictive value of TEXscore towards immune checkpoint blockers in independent cohorts. (A) ROC curve suggested that TEXscore exerted inferior predictive capacity to ICB response in GSE91061 cohort. (TEXscore: AUC = 0.64, CD8+ T cells: AUC = 0.622, GEP: AUC = 0.607). (B) Rate of clinical response (non-response (NR) and response (R)) to ICB in high or low TEXscore groups in the GSE91061 cohort. (C) ROC curve suggested that TEXscore exerted inferior predictive capacity to ICB response in GSE78220 cohort. (TEXscore: AUC = 0.607, CD8 + T cells: AUC = 0.542, GEP: AUC = 0.571). (D) Rate of clinical response (NR and R) to ICB in high or low TEXscore groups in the GSE78220 cohort. (E) ROC curve suggested that TEXscore exerted inferior predictive capacity to ICB response in GSE67501 cohort. (TEXscore: AUC = 0.75, CD8 + T cells: AUC = 0.607, GEP: AUC = 0.464). (F) Rate of clinical response (NR and R) to ICB in high or low TEXscore groups in the GSE67501 cohort. (G) IC level represented PD-L1 expression on tumour-infiltrating immune cells through immunohistochemistry (IHC). IC level was not related to the TEXscore. Specimens were scored as IHC IC0, IC1, or IC2 if