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d-allulose Ameliorates Metabolic Dysfunction in C57BL/KsJ-db/db Mice
- Source :
- Molecules, Volume 25, Issue 16, Molecules, Vol 25, Iss 3656, p 3656 (2020)
- Publication Year :
- 2020
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2020.
-
Abstract
- d-allulose is an uncommon sugar that provides almost no calories when consumed. Its sweetness is 70% that of sucrose. d-allulose is a metabolic regulator of glucose and lipid metabolism. However, few reports concerning its effect on diabetes and related metabolic disturbances in db/db mice are available. In this study, we evaluated d-allulose&rsquo<br />s effect on hyperglycemia, hyperinsulinemia, diabetes and inflammatory responses in C57BL/KsJ-db/db mice. Mice were divided into normal diet, erythritol supplemented (5% w/w), and d-allulose supplemented (5% w/w) groups. Blood glucose and plasma glucagon levels and homeostatic model assessment (HOMA-IR) were significantly lower in the d-allulose group than in the normal diet group, and plasma insulin level was significantly increased. Further, d-allulose supplement significantly increased hepatic glucokinase activity and decreased hepatic phosphoenolpyruvate carboxykinase and glucose-6-phosphatase activity. Expression of glucose transporter 4, insulin receptor substrate 1, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha and AKT serine/threonine kinase 2 were also upregulated by d-allulose supplement in adipocyte and muscle. Finally, d-allulose effectively lowered plasma and hepatic triglyceride and free fatty acid levels, and simultaneously reduced hepatic fatty acid oxidation and carnitine palmitoyl transferase activity. These changes are likely attributable to suppression of hepatic fatty acid synthase and glucose-6-phosphate dehydrogenase activity. Notably, d-allulose also reduced pro-inflammatory adipokine and cytokine levels in plasma. Our results indicate that d-allulose is an effective sugar substitute for improving lipid and glucose metabolism.
- Subjects :
- Blood Glucose
Male
type 2 diabetes mellitus
Pharmaceutical Science
Analytical Chemistry
Mice
chemistry.chemical_compound
0302 clinical medicine
Drug Discovery
Hyperinsulinemia
Insulin
0303 health sciences
biology
Lipids
Fatty acid synthase
Chemistry (miscellaneous)
Molecular Medicine
medicine.drug
medicine.medical_specialty
sugar substitute
Normal diet
Mice, Inbred Strains
030209 endocrinology & metabolism
Fructose
Carbohydrate metabolism
Article
d-allulose
metabolic syndrome
Diabetes Mellitus, Experimental
lcsh:QD241-441
03 medical and health sciences
lcsh:Organic chemistry
d-allulose%22">d-allulose
Hyperinsulinism
Internal medicine
medicine
Animals
Carnitine
Physical and Theoretical Chemistry
030304 developmental biology
Inflammation
Triglyceride
Organic Chemistry
Glucose transporter
medicine.disease
IRS1
Mice, Inbred C57BL
Endocrinology
chemistry
Hyperglycemia
biology.protein
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....0196dfb429aa1e2dbfd4b563b1120d1f
- Full Text :
- https://doi.org/10.3390/molecules25163656