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Genotoxicity of three biofuel candidates compared to reference fuels
- Source :
- Environmental toxicology and pharmacology. 64
- Publication Year :
- 2018
-
Abstract
- Global demand for alternative energy sources increases due to concerns regarding energy security and greenhouse gas emissions. However, little is known regarding the impacts of biofuels to the environment and human health even though the identification of such impacts is important to avoid biofuels leading to undesired effects. In this study mutagenicity and genotoxicity of the three biofuel candidates ethyl levulinate (EL), 2-methyltetrahydrofuran (2-MTHF) and 2-methylfuran (2-MF) were investigated in comparison to two petroleum-derived fuels and a biodiesel. None of the samples induced mutagenicity in the Ames fluctuation test. However, the Micronucleus assay revealed significant effects in Chinese hamster (Cricetulus griseus) V79 cells caused by the potential biofuels. 2-MF revealed the highest toxic potential with significant induction of micronuclei below 20.0 mg/L. EL and 2-MTHF induced micronuclei only at very high concentrations (>1000.0 mg/L). In regard to the genotoxic potential of 2-MF, its usage as biofuel should be critically discussed.
- Subjects :
- 0301 basic medicine
Salmonella typhimurium
Health, Toxicology and Mutagenesis
010501 environmental sciences
Toxicology
medicine.disease_cause
01 natural sciences
Cell Line
03 medical and health sciences
Cricetulus
Bioenergy
medicine
Animals
Food science
Furans
Micronuclei, Chromosome-Defective
0105 earth and related environmental sciences
Pharmacology
Biodiesel
business.industry
Chemistry
Mutagenicity Tests
General Medicine
Energy security
Levulinic Acids
030104 developmental biology
Biofuel
Greenhouse gas
Biofuels
Micronucleus test
Alternative energy
business
Genotoxicity
Mutagens
Subjects
Details
- ISSN :
- 18727077
- Volume :
- 64
- Database :
- OpenAIRE
- Journal :
- Environmental toxicology and pharmacology
- Accession number :
- edsair.doi.dedup.....0191f87d3d0b9eb3b8a30836417b7e7a