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Food insecurity, drug resistance and non-disclosure are associated with virologic non-suppression among HIV pregnant women on antiretroviral treatment
- Source :
- PLoS ONE, Vol 16, Iss 8, p e0256249 (2021), PLoS ONE
- Publication Year :
- 2021
- Publisher :
- Public Library of Science (PLoS), 2021.
-
Abstract
- We determined social and behavioral factors associated with virologic non-suppression among pregnant women receiving Option B+ antiretroviral treatment (ART). Baseline data was used from women in Mobile WAChX trial from 6 public maternal child health (MCH) clinics in Kenya. Virologic non-suppression was defined as HIV viral load (VL) ≥1000 copies/ml. Antiretroviral resistance testing was performed using oligonucleotide ligation (OLA) assay. ART adherence information, motivation and behavioral skills were assessed using Lifewindows IMB tool, depression using PHQ-9, and food insecurity with the Household Food Insecurity Access Scale. Correlates of virologic non-suppression were assessed using Poisson regression. Among 470 pregnant women on ART ≥4 months, 57 (12.1%) had virologic non-suppression, of whom 65% had HIV drug resistance mutations. In univariate analyses, risk of virologic non-suppression was associated with moderate-to-severe food insecurity (RR 1.80 [95% CI 1.06–3.05]), and varied significantly by clinic site (range 2%-22%, p
- Subjects :
- RNA viruses
Multivariate analysis
Epidemiology
Maternal Health
Gene Identification and Analysis
Social Sciences
HIV Infections
Drug resistance
Pathology and Laboratory Medicine
Immunodeficiency Viruses
Pregnancy
Antiretroviral Therapy, Highly Active
Medicine and Health Sciences
Psychology
Public and Occupational Health
Univariate analysis
Multidisciplinary
Antimicrobials
Age Factors
Obstetrics and Gynecology
Drugs
Antiretrovirals
Viral Load
Antivirals
Vaccination and Immunization
Medical Microbiology
Viral Pathogens
Viruses
RNA, Viral
Medicine
Female
Pathogens
Viral load
Confidentiality
HIV drug resistance
Research Article
Adult
medicine.medical_specialty
Anti-HIV Agents
Science
Immunology
Antiretroviral Therapy
Lower risk
Microbiology
Medication Adherence
Social support
Antiviral Therapy
Microbial Control
Virology
Internal medicine
Drug Resistance, Viral
Retroviruses
Genetics
medicine
Humans
Microbial Pathogens
Mutation Detection
Pharmacology
Behavior
Motivation
business.industry
Lentivirus
Organisms
Cognitive Psychology
Social Support
Biology and Life Sciences
HIV
medicine.disease
Kenya
Health Care
Food Insecurity
Health Care Facilities
Medical Risk Factors
HIV-1
Women's Health
Cognitive Science
Preventive Medicine
business
Neuroscience
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- PLOS ONE
- Accession number :
- edsair.doi.dedup.....018e1a47aebf778c3ecf91b89bae8124