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Identification of familial colorectal cancer and hereditary colorectal cancer syndromes through the Dutch population-screening program: results ofa pilot study
- Source :
- Scandinavian Journal of Gastroenterology, 51(10), 1227-1232. Informa Healthcare, Scandinavian Journal of Gastroenterology, 51(10), 1227-1232. TAYLOR & FRANCIS LTD, Scandinavian Journal of Gastroenterology
- Publication Year :
- 2016
- Publisher :
- TAYLOR & FRANCIS LTD, 2016.
-
Abstract
- Objectives: In 2014, a population-screening program using immuno-faecal occult blood testing (I-FOBT) has started in the Netherlands. The aims of this study were to evaluate the proportion of individuals in the Dutch screening program with a positive I-FOBT that fulfill the criteria for familial colorectal cancer (FCC) and to evaluate the proportion of participants that needs genetic counseling or colonoscopic surveillance.Material and methods: This retrospective observational study was performed in two large hospitals. Individuals aged between 55 and 75 years with a positive I-FOBT that underwent colonoscopy were included. A detailed family history was obtained in all individuals.Results: A total of 657 individuals with a positive I-FOBT test underwent colonoscopy. A total of 120 (18.3%) participants were found to have a positive family history for CRC, 20 (3.0%) fulfilled the FCC criteria, 4 (0.6%) the Bethesda guidelines and 1 (0.2%) participant the Amsterdam criteria. Multiple adenomas (>10) were found in 21 (3.2%) participants. No cases of serrated polyposis were identified. Based on these criteria and guidelines, a total of 35 (5.3%) required referral to the clinical geneticist and the relatives of 20 (3.0%) participants should be referred for surveillance colonoscopy.Conclusion: Obtaining a detailed family history at the time of intake of participants with a positive I-FOBT in the Dutch surveillance program increased the identification of participants with familial CRC.
- Subjects :
- Adenoma
Counseling
Male
Amsterdam criteria
medicine.medical_specialty
Colorectal cancer
Genetic counseling
Colonoscopy
Pilot Projects
familial colorectal cancer
screening program
Article
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
Mass Screening
Family history
Referral and Consultation
Mass screening
Aged
Netherlands
Retrospective Studies
Gynecology
genetic counseling
medicine.diagnostic_test
business.industry
immuno-faecal occult blood testing
Gastroenterology
Retrospective cohort study
Middle Aged
medicine.disease
Colorectal Neoplasms, Hereditary Nonpolyposis
Occult
digestive system diseases
Occult Blood
Population Surveillance
030220 oncology & carcinogenesis
surveillance
Female
Original Article
030211 gastroenterology & hepatology
business
Subjects
Details
- Language :
- English
- ISSN :
- 00365521
- Database :
- OpenAIRE
- Journal :
- Scandinavian Journal of Gastroenterology, 51(10), 1227-1232. Informa Healthcare, Scandinavian Journal of Gastroenterology, 51(10), 1227-1232. TAYLOR & FRANCIS LTD, Scandinavian Journal of Gastroenterology
- Accession number :
- edsair.doi.dedup.....0186145ea2ab35f16f01a38a4c207ad5