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Cardiac Steatosis in HIV-A Marker or Mediator of Disease?
- Source :
- Frontiers in Endocrinology, Frontiers in Endocrinology, Vol 9 (2018)
- Publication Year :
- 2018
- Publisher :
- Frontiers Media S.A., 2018.
-
Abstract
- Although people living with HIV (PLHIV) are approaching normal life expectancy, a limitation to achieving this goal is managing the higher prevalence of co-morbidities, including cardiovascular disease. Whilst ischaemic heart disease likely contributes to a large proportion of cardiac disease in the modern era of treatment, cardio-metabolic disease, including cardiac steatosis, akin to obesity-related heart disease, is also a possible mechanism of increased cardiac morbidity and mortality. HIV and other metabolic and inflammatory diseases affecting the heart, including obesity, share many cardio-metabolic abnormalities, with increased pericardial and myocardial fat content, in association with chronic systemic inflammatory changes and alterations in cardiac metabolism. Understanding the mechanisms of HIV-associated cardiac steatosis remains an important challenge, as managing the untreated metabolic and inflammatory precipitants may substantially improve cardiac outcomes for PLHIV.
- Subjects :
- medicine.medical_specialty
Heart disease
Endocrinology, Diabetes and Metabolism
Mini Review
Disease
030204 cardiovascular system & hematology
Systemic inflammation
lcsh:Diseases of the endocrine glands. Clinical endocrinology
03 medical and health sciences
0302 clinical medicine
Mediator
Endocrinology
cardiovascular disease
Internal medicine
medicine
030212 general & internal medicine
metabolic dysregulation
systemic inflammation
lcsh:RC648-665
Mechanism (biology)
business.industry
pericardial fat
HIV
medicine.disease
Obesity
cardiac steatosis
Cardiology
Life expectancy
cardiovascular system
Steatosis
medicine.symptom
business
Subjects
Details
- Language :
- English
- ISSN :
- 16642392
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Frontiers in Endocrinology
- Accession number :
- edsair.doi.dedup.....0180794bf9385a67c3ff83d4e0accad6