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Silver-catalyzed spirolactonization: first synthesis of spiroisoindole-γ-methylene-γ-butyrolactones
- Source :
- Tetrahedron, Tetrahedron, Elsevier, 2008, 64 (16), pp.3505-3516. ⟨10.1016/j.tet.2008.01.137⟩
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- γ-Acetylenic carboxylic acids are cyclized to spirolactones under mild conditions, in the presence of Ag2CO3 catalyst. The corresponding spiro-5-alkylidene-γ-butyrolactones were isolated in high yields, and this process constitutes an easy and efficient route to analogous structures of natural products of biological interest.
- Subjects :
- [CHIM.ORGA]Chemical Sciences/Organic chemistry
010405 organic chemistry
Organic Chemistry
[CHIM.CATA]Chemical Sciences/Catalysis
010402 general chemistry
01 natural sciences
Biochemistry
0104 chemical sciences
Catalysis
chemistry.chemical_compound
chemistry
Drug Discovery
[CHIM]Chemical Sciences
Organic chemistry
Methylene
ComputingMilieux_MISCELLANEOUS
Subjects
Details
- ISSN :
- 00404020
- Volume :
- 64
- Database :
- OpenAIRE
- Journal :
- Tetrahedron
- Accession number :
- edsair.doi.dedup.....01743934905cb875c4c8fba109cf193a
- Full Text :
- https://doi.org/10.1016/j.tet.2008.01.137