Additional file 1: Table S1. of SOX5 is involved in balanced MITF regulation in human melanoma cells

Correlation of activity parameter for all putative MITF TFs with MITF expression levels for the NCI-60 panel. Table S2. Comparison of expression levels of SOX5 to different SOX family members (from the SKCM samples). Figure S1. Shows density plot of TBA z-scores for all TFs and target genes. Figure S2. Shows map of the used lentiviral vector MITFP-pLenti. Figure S3. Validation of the functionality of the melanocyte-specific lentiviral reporter vector MITFP-pLenti by comparing melanocytes and fibroblasts. Figure S4. Hierarchical cluster analysis of the NCI-60 cell line panel based on SOX10, SOX5 and MITF expression. Figure S5. Validation of siRNA mediated knock-down of SOX5 by qRT-PCR. Figure S6. Results of cell viability assay after transfection with SOX5 siRNA pool for five melanoma cell lines. Figure S7. Results of invasion assay after transfection with SOX5 siRNA pool. Figure S8. Boxplot SOX5 expression for primary and distant metastasis samples. Figure S9. Histogram of SOX5 expression for SCKM samples with vital status dead. Figure S10. Bimodal distribution of SOX5 expression for thick subgroup of the SKCM samples with Breslow thickness > 4 mm. Figure S11. Density and histogram of SOX5 expression for melanoma samples from the 33 melanoma cell lines. Figure S12. Kaplan-Meier analysis of SKCM samples based on MITF expression. (DOCX 1173 kb)