Back to Search
Start Over
In-depth analysis of the origins of HIV type 1 subtype C in South America
- Publication Year :
- 2009
- Publisher :
- Mary Ann Liebert, 2009.
-
Abstract
- The South American HIV-1 epidemic is characterized by the cocirculation of subtype B and BF recombinant variants. Together with the B and BF genotypes, HIV-1 subtype C (HIV-1C), F1, and several other recombinants have been reported. The epidemiological significance and immune correlates of these "non-B-non-BF" strains circulating in South America are still uncertain and therefore are increasingly attracting the interest of the scientific community. In this study, the South American HIV-1C epidemic was studied using new technologies for the phylogenetic analysis of large datasets. Our results indicate that there is a major clade encompassing most of the South American HIV-1C strains. These analyses also agreed that some strains do not group inside this major clade, suggesting that there could be HIV-1C sequences of different origins circulating in South America. Others have proposed different hypotheses about the origins of HIV-1C strains from South America. This study shows that an exact single origin cannot be determined, a fact that could be attributed to sampling problems, phylogenetic uncertainty, and the shortage of historical and epidemiological data. Currently, the reported data indicate that HIV-1C strains were introduced in Brazil and afterward spread to other regions of South America. By using character optimization on the obtained phylogenetic trees, we observed that Argentina could also be a point in which the HIV-1C epidemic entered South America. Fil: Jones, Leandro Roberto. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Centro Nacional de Referencia para el Sida; Argentina. Fundación Playa Unión. Estación de Fotobiología Playa Unión; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Dilernia, Darío Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Centro Nacional de Referencia para el Sida; Argentina Fil: Manrique, Julieta Marina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química Analítica Instrumental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Moretti, Franco. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Centro Nacional de Referencia para el Sida; Argentina Fil: Salomon, Horacio Eduardo. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Centro Nacional de Referencia para el Sida; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Gómez Carrillo, Manuel. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Centro Nacional de Referencia para el Sida; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
- Subjects :
- Sequence analysis
Immunology
Molecular Sequence Data
Human immunodeficiency virus (HIV)
Sequence Homology
HIV Infections
medicine.disease_cause
Ciencias Biológicas
Type (biology)
Origin
Phylogenetics
Virology
Genotype
medicine
Cluster Analysis
Humans
Clade
Phylogeny
Ciencias de las Plantas, Botánica
Molecular Epidemiology
Molecular epidemiology
Phylogenetic tree
business.industry
HIV
Sequence Analysis, DNA
South America
Infectious Diseases
Evolutionary biology
HIV-1
Subtype C Epidemic
business
CIENCIAS NATURALES Y EXACTAS
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....017030e70b179dcd1c49e7ac6a157d73