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Prevalence and short‐term changes of cognitive dysfunction in young ischaemic stroke patients
- Source :
- European Journal of Neurology
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- Background and purpose Information on the prevalence and course of post‐stroke cognitive impairment in young stroke patients is limited. The aim was to assess a consecutive sample of acute young ischaemic stroke patients (18–55 years) for the presence and development of neuropsychological deficits. Methods Patients prospectively underwent a comprehensive clinical and cognitive assessment, examining general cognitive function, processing speed, attention, flexibility/executive function and word fluency within the first 3 weeks after hospital admission (median assessment at day 6) and at a 3 months’ follow‐up (FU). Cognitive dysfunction was defined in comparison to age‐standardized published norms. Results At baseline (N = 114), deficits were highly prevalent in processing speed (56.0%), flexibility/executive function (49.5%), attention (46.4%) and general cognitive function (42.1%). These frequencies were comparable for those with FU assessment (N = 87). In most domains, cognitive performance improved within 3 months, except for word fluency. However, in about one‐third of patients, cognitive deficits (as defined by 1.5 standard deviations below the standardized mean) were still present 3 months after stroke. At FU, 44.0% were impaired in the domain flexibility/executive function, 35.0% in processing speed and 30.0% in attention. Conclusions The high prevalence of cognitive deficits in acute young patients with ischaemic stroke highlights the importance of early post‐stroke cognitive assessment to capture a patient's dysfunction in a comprehensive manner and to offer adequate rehabilitation. The role of factors which promote neuropsychological deficits needs further exploration.
- Subjects :
- cognition
Adult
Male
medicine.medical_specialty
Adolescent
medicine.medical_treatment
changes
Neuropsychological Tests
Brain Ischemia
Executive Function
Young Adult
03 medical and health sciences
0302 clinical medicine
Physical medicine and rehabilitation
Ischaemic stroke
Prevalence
medicine
processing speed
Humans
Speech
Attention
Cognitive Dysfunction
Prospective Studies
030212 general & internal medicine
Effects of sleep deprivation on cognitive performance
Stroke
Rehabilitation
young
business.industry
Age Factors
Neuropsychology
acute
Flexibility (personality)
Cognition
Original Articles
Middle Aged
medicine.disease
stroke
Neurology
Disease Progression
Original Article
Female
Neurology (clinical)
Cognitive Assessment System
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 14681331 and 13515101
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- European Journal of Neurology
- Accession number :
- edsair.doi.dedup.....016c39b8d9dbc084567f7ea998ac7446
- Full Text :
- https://doi.org/10.1111/ene.13879