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Factors associated with dizygotic twinning after IVF treatment with double embryo transfer

Authors :
Groeneveld, E.
Lambers, M.J.
Stakelbeek, M.E.
Mooij, T.M.
van den Belt-Dusebout, A.W.
Heymans, M.W.
Schats, R.
Hompes, P.G.
Hoek, A.
Burger, C.W.
van Leeuwen, F.E.
Lambalk, C.B.
Kortman, M.
Laven, J.S.E.
Jansen, C.A
Helmerhorst, F.M.
Cohlen, B.J.
Braat, D.D.M.
Smeenk, J.M.
Simons, A.H.
Veen, F. van der
Evers, J.L.
Dop, P.A. van
Reproductive Origins of Adult Health and Disease (ROAHD)
Obstetrics and gynaecology
Epidemiology and Data Science
VU University medical center
EMGO - Quality of care
ICaR - Ischemia and repair
Amsterdam Reproduction & Development (AR&D)
Psychiatrie & Neuropsychologie
Obstetrie & Gynaecologie
RS: GROW - School for Oncology and Reproduction
Methodology and Applied Biostatistics
EMGO+ - Quality of Care
Erasmus MC other
Obstetrics & Gynecology
NCA - Hormones and the Brain
EMGO - Musculoskeletal health
EMGO+ - Musculoskeletal Health
Neuroscience Campus Amsterdam - Homones and the Brain
Source :
Human Reproduction, 27, 10, pp. 2966-70, Human Reproduction, 27(10), 2966-2970. Oxford University Press, Human Reproduction, 26(supplement 1), I33-I33. Oxford University Press, Human Reproduction, 27, 2966-70, Lambers, M J, Groeneveld, E, Stakelbeek, M E F, van den Belt-Dusebout, A W, de Mooij, Y M, Heijmans, M W, Schats, R, Hompes, P G A, Hoek, A, Burger, C, van Leeuwen, F E & Lambalk, C B 2011, ' Factors associated with dizygotic twinning after IVF treatment with double embryo transfer ', Human Reproduction, vol. 26, no. supplement 1, pp. I33-I33 ., Groeneveld, E, Lambers, M J, Stakelbeek, M E F, Mooij, T M, van den Belt-Dusebout, A W, Heijmans, M W, Schats, R, Hompes, P G A, Hoek, A, Burger, C W, van Leeuwen, F E & Lambalk, C B 2012, ' Factors associated with dizygotic twinning after IVF treatment with double embryo transfer ', Human Reproduction, vol. 27, no. 10, pp. 2966-2970 . https://doi.org/10.1093/humrep/des258
Publication Year :
2012

Abstract

Item does not contain fulltext BACKGROUND: Dizygotic twin pregnancies after IVF treatment are the result of multiple embryos transferred into the uterine cavity, followed by successful double implantation. Factors that increase the chance of multiple implantation after IVF are relatively unknown. The present study aimed to investigate whether features of body composition, such as maternal height, weight and body mass index (BMI) are associated with an increased chance of dizygotic twinning after IVF with double embryo transfer (DET). METHODS: This study was conducted using data from a large Dutch nationwide cohort that comprised 19 861 women who had IVF or ICSI treatment between 1983 and 1995 (OMEGA study). First 'fresh' IVF and ICSI cycles with DET resulting in a delivery of a singleton or twin (living as well as stillborn) were selected. A multivariable logistic regression analysis was performed, with the delivery of a singleton or twin as the dependent variable and height, weight, BMI, maternal age, number of retrieved oocytes, use of alcohol, smoking, highest level of education and parity as independent variables. RESULTS: Of the 6598 women who completed their first IVF or ICSI cycle, 2375 had DET, resulting in 496 deliveries of 371 singletons and 125 twins. Multivariable regression analysis revealed that tall women (>1.74 cm) and women with a high number of retrieved oocytes (>8) had an increased chance of dizygotic twinning [OR: 1.8 (95% CI: 1.0-3.4) and OR: 2.2 (95% CI: 1.3-3.8), respectively]. CONCLUSIONS: Our data demonstrate that tall stature and increased number of retrieved oocytes independently increase the chance of dizygotic twinning after IVF with DET.

Details

ISSN :
14602350 and 02681161
Database :
OpenAIRE
Journal :
Human Reproduction, 27, 10, pp. 2966-70, Human Reproduction, 27(10), 2966-2970. Oxford University Press, Human Reproduction, 26(supplement 1), I33-I33. Oxford University Press, Human Reproduction, 27, 2966-70, Lambers, M J, Groeneveld, E, Stakelbeek, M E F, van den Belt-Dusebout, A W, de Mooij, Y M, Heijmans, M W, Schats, R, Hompes, P G A, Hoek, A, Burger, C, van Leeuwen, F E & Lambalk, C B 2011, ' Factors associated with dizygotic twinning after IVF treatment with double embryo transfer ', Human Reproduction, vol. 26, no. supplement 1, pp. I33-I33 ., Groeneveld, E, Lambers, M J, Stakelbeek, M E F, Mooij, T M, van den Belt-Dusebout, A W, Heijmans, M W, Schats, R, Hompes, P G A, Hoek, A, Burger, C W, van Leeuwen, F E & Lambalk, C B 2012, ' Factors associated with dizygotic twinning after IVF treatment with double embryo transfer ', Human Reproduction, vol. 27, no. 10, pp. 2966-2970 . https://doi.org/10.1093/humrep/des258
Accession number :
edsair.doi.dedup.....01657bb13e846860640195252e72ad93