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Effect of Saxagliptin on Renal Outcomes in the SAVOR-TIMI 53 Trial
- Source :
- Diabetes Care. 40:69-76
- Publication Year :
- 2016
- Publisher :
- American Diabetes Association, 2016.
-
Abstract
- OBJECTIVEDipeptidyl peptidase 4 inhibitors may have a protective effect in diabetic nephropathy.RESEARCH DESIGN AND METHODSWe studied renal outcomes of 16,492 patients with type 2 diabetes, randomized to saxagliptin versus placebo and followed for a median of 2.1 years in the Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus–Thrombolysis in Myocardial Infarction 53 (SAVOR-TIMI 53) trial.RESULTSAt baseline, 9,696 (58.8%) subjects had normoalbuminuria (albumin/creatinine ratio [ACR] 300 mg/g). Treatment with saxagliptin was associated with improvement in and/or less deterioration in ACR categories from baseline to end of trial (EOT) (P = 0.021, P < 0.001, and P = 0.049 for individuals with baseline normoalbuminuria, microalbuminuria, and macroalbuminuria, respectively). At 2 years, the difference in mean ACR change between saxagliptin and placebo arms was −19.3 mg/g (P = 0.033) for estimated glomerular filtration rate (eGFR) >50 mL/min/body surface area per 1.73 m2 (BSA), −105 mg/g (P = 0.011) for 50 ≥ eGFR ≥ 30 mL/min/BSA, and −245.2 mg/g (P = 0.086) for eGFR 6.0 mg/dL, were similar as well.CONCLUSIONSTreatment with saxagliptin improved ACR, even in the normoalbuminuric range, without affecting eGFR. The beneficial effect of saxagliptin on albuminuria could not be explained by its effect on glycemic control.
- Subjects :
- CHRONIC KIDNEY-DISEASE
Blood Glucose
Male
Endocrinology, Diabetes and Metabolism
Adamantane
Type 2 diabetes
030204 cardiovascular system & hematology
Saxagliptin
chemistry.chemical_compound
0302 clinical medicine
Diabetic Nephropathies
Body surface area
POST-HOC ANALYSIS
CARDIOVASCULAR RISK
PROTEINURIA
11 Medical And Health Sciences
Dipeptides
Middle Aged
Creatinine
Female
medicine.symptom
Life Sciences & Biomedicine
TIMI
Glomerular Filtration Rate
medicine.medical_specialty
NEPHROPATHY
INHIBITION
Urology
Renal function
030209 endocrinology & metabolism
Endocrinology & Metabolism
03 medical and health sciences
Double-Blind Method
Internal medicine
Internal Medicine
medicine
Albuminuria
Humans
INDUCED DIABETIC-RATS
Serum Albumin
Aged
Advanced and Specialized Nursing
Dipeptidyl-Peptidase IV Inhibitors
Science & Technology
business.industry
MICROALBUMINURIA
medicine.disease
REDUCTION
Endocrinology
Diabetes Mellitus, Type 2
chemistry
Microalbuminuria
business
Subjects
Details
- ISSN :
- 19355548 and 01495992
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Diabetes Care
- Accession number :
- edsair.doi.dedup.....016028a9271d22382d6a8140f2ec2304