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More than just acral melanoma: the controversies of defining the disease
- Source :
- The Journal of Pathology: Clinical Research, Vol 7, Iss 6, Pp 531-541 (2021), The Journal of Pathology: Clinical Research
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Acral melanoma (AM) is a malignant cutaneous melanocytic tumour specifically located on the palms, soles, and nail apparatus, which are areas of glabrous (hairless) skin. Acral lentiginous melanoma, a subtype of AM, represents a histopathological subtype diagnosis of cutaneous melanoma with unique morphological and structural features. Despite clear definitions, the misuse of these terms and the inconsistency in reporting the histopathological features of AM cases have become a major obstacle to the study of the disease. In this review, we discuss the epidemiology, histopathological features, prognosis, and genetic profile of AM, highlighting the differences observed when histopathological subtypes are considered. The increasing global effort to characterise AM cases from ethnically diverse populations would benefit greatly from a more consistent classification of the disease.
- Subjects :
- medicine.medical_specialty
Skin Neoplasms
Review
Disease
Acral lentiginous melanoma
Pathology and Forensic Medicine
Epidemiology
Biomarkers, Tumor
medicine
Pathology
Animals
Humans
RB1-214
genetics
skin and connective tissue diseases
Melanoma
Nail Apparatus
Dermatologie
integumentary system
Foot
business.industry
Hand
medicine.disease
Dermatology
Hairless
acral melanoma
Nails
Anatomopathologie
Acral melanoma
Cutaneous melanoma
histopathology
Histopathology
epidemiology
prognosis
business
Subjects
Details
- Language :
- English
- ISSN :
- 20564538
- Volume :
- 7
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- The Journal of Pathology: Clinical Research
- Accession number :
- edsair.doi.dedup.....01575b1415650efaed3ec70a62259bd7