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PCNA on the crossroad of cancer
- Source :
- Biochemical Society transactions. 37(Pt 3)
- Publication Year :
- 2009
-
Abstract
- Cancer is caused by genetic changes that often arise following failure to accurately replicate the DNA. PCNA (proliferating-cell nuclear antigen) forms a ring around the DNA to facilitate and control DNA replication. Emerging evidence suggests that PCNA is at the very heart of many essential cellular processes, such as DNA replication, repair of DNA damage, chromatin structure maintenance, chromosome segregation and cell-cycle progression. Progression of the DNA replication forks can be blocked by DNA lesions, formed either by endogenous damage or by exogenous agents, for instance anticancer drugs. Cellular response often results in change of PCNA function triggered either by specific post-translational modification of PCNA (i.e. ubiquitylation) or by exchange of its interaction partners. This puts PCNA in a central position in determining the fate of the replication fork. In the present article, we review PCNA modifications and interaction partners, and how those influence the course of events at replication forks, which ultimately determines both tumour progression as well as the outcome of anticancer treatment.
- Subjects :
- DNA Replication
Models, Molecular
DNA Repair
DNA repair
DNA damage
Protein Conformation
Molecular Sequence Data
Eukaryotic DNA replication
Cell Cycle Proteins
Biology
Biochemistry
Control of chromosome duplication
Neoplasms
Proliferating Cell Nuclear Antigen
Animals
Humans
Amino Acid Sequence
Binding Sites
Sequence Homology, Amino Acid
Cell Cycle
DNA replication
Molecular biology
Chromatin
Proliferating cell nuclear antigen
Cell biology
biology.protein
DNA mismatch repair
Protein Processing, Post-Translational
DNA Damage
Protein Binding
Subjects
Details
- ISSN :
- 14708752
- Volume :
- 37
- Issue :
- Pt 3
- Database :
- OpenAIRE
- Journal :
- Biochemical Society transactions
- Accession number :
- edsair.doi.dedup.....0145dce1a926352141a357ae13eab37f