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Aromadendrine, a new component of the flavonoid pattern of Olea europaea L. and its anti-inflammatory activity
- Source :
- Natural product research. 27(4-5)
- Publication Year :
- 2012
-
Abstract
- Leaves of Olea europaea, cultivar Nocellara del Belice, were examined with respect to the medium-polar fraction, obtained by an ethyl acetate extraction of the whole extract. In the medium polar fraction, we isolated the two hydroxy-phenyl-ethyl alcohols (hydroxyl-tyrosol and tyrosol) that are the main component of olives. In addition, we isolated a flavonoidic compound, aromadendrine, a dihydroflavonol yet known but quite rare in nature. It is the first time that aromadendrine is isolated in O. europaea and we studied the aromadendrine biological activity. In particular, the ability of aromadendrine to reduce the inflammation induced in normal keratinocytes using an in vitro cell model was evaluated. The results of the present research indicate aromadendrine as a novel component in O. europaea with effective activity against skin inflammation.
- Subjects :
- medicine.drug_class
Cell Survival
Flavonoid
Ethyl acetate
Anti-Inflammatory Agents
Enzyme-Linked Immunosorbent Assay
Plant Science
Biochemistry
Anti-inflammatory
Analytical Chemistry
Cell Line
chemistry.chemical_compound
Olea
medicine
Humans
Normal keratinocytes
Chemokine CCL2
aromadendrine
dihydroflavonol
flavonoids
olea europaea
chemistry.chemical_classification
Flavonoids
biology
Organic Chemistry
Extraction (chemistry)
Interleukin-8
Biological activity
biology.organism_classification
Tyrosol
chemistry
Subjects
Details
- ISSN :
- 14786427
- Volume :
- 27
- Issue :
- 4-5
- Database :
- OpenAIRE
- Journal :
- Natural product research
- Accession number :
- edsair.doi.dedup.....014390f3b4c95ee9d25202fdffc47b00