Back to Search
Start Over
Prevalence and Predictors of Functional Vitamin K Insufficiency in Mothers and Newborns in Uganda
- Source :
- Nutrients, Vol 7, Iss 10, Pp 8545-8552 (2015), Nutrients, Volume 7, Issue 10, Pages 8545-8552, Nutrients; Volume 7; Issue 10; Pages: 8545-8552
- Publication Year :
- 2015
- Publisher :
- MDPI AG, 2015.
-
Abstract
- Vitamin K deficiency bleeding (VKDB) in infancy is a serious but preventable cause of mortality or permanent disability. Lack of epidemiologic data for VKDB in sub-Saharan Africa hinders development and implementation of effective prevention strategies. We used convenience sampling to consecutively enroll mothers delivering in a southwestern Uganda Hospital. We collected socio-demographic and dietary information, and paired samples of maternal venous and neonatal cord blood for the immunoassay of undercarboxylated prothrombin (PIVKA-II), a sensitive marker of functional vitamin K (VK) insufficiency. We used univariable and multivariable logistic regression models to identify predictors of VK insufficiency. We detected PIVKA-II of ≥0.2 AU (Arbitrary Units per mL)/mL (indicative of VK insufficiency) in 33.3% (47/141) of mothers and 66% (93/141) of newborns. Importantly, 22% of babies had PIVKA-II concentrations ≥5.0 AU/mL, likely to be associated with abnormal coagulation indices. We found no significant predictors of newborn VK insufficiency, including infant weight (AOR (adjusted odds ratio) 1.85, 95% CI (confidence interval) 0.15-22.49), gender (AOR 0.54, 95% CI 0.26-1.11), term birth (AOR 0.72, 95% CI 0.20-2.62), maternal VK-rich diet (AOR 1.13, 95% CI 0.55-2.35) or maternal VK insufficiency (AOR 0.99, 95% CI 0.47-2.10). VK insufficiency is common among mothers and newborn babies in southwestern Uganda, which in one fifth of babies nears overt deficiency. Lack of identifiable predictors of newborn VK insufficiency support strategies for universal VK prophylaxis to newborns to prevent VKDB.
- Subjects :
- Adult
Male
Pediatrics
medicine.medical_specialty
Population
Nutritional Status
lcsh:TX341-641
Logistic regression
Article
vitamin K
Young Adult
Pregnancy
newborn
Vitamin K deficiency
Humans
Medicine
Uganda
Protein Precursors
Young adult
education
Prenatal Nutritional Physiological Phenomena
education.field_of_study
Nutrition and Dietetics
business.industry
Infant, Newborn
Odds ratio
deficiency
Vitamin K Deficiency Bleeding
medicine.disease
bleeding
Confidence interval
Pregnancy Complications
insufficiency
Logistic Models
undercarboxylated prothrombin
haemorrhage
prophylaxis
Term Birth
Female
Prothrombin
Vitamin K Deficiency
business
lcsh:Nutrition. Foods and food supply
Biomarkers
Food Science
Subjects
Details
- Language :
- English
- ISSN :
- 20726643
- Volume :
- 7
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....013bb999148805f2f584686e26465ea1