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High-resolution CT by diffraction-enhanced x-ray imaging: mapping of breast tissue samples and comparison with their histo-pathology
- Source :
- Physics in Medicine and Biology, Physics in Medicine and Biology, IOP Publishing, 2007, 52 (8), pp.2197-211. ⟨10.1088/0031-9155/52/8/011⟩
- Publication Year :
- 2007
- Publisher :
- IOP Publishing, 2007.
-
Abstract
- International audience; The aim of this study was to introduce high-resolution computed tomography (CT) of breast tumours using the diffraction-enhanced x-ray imaging (DEI) technique and to compare results with radiological and histo-pathological examinations. X-ray CT images of tumour-bearing breast tissue samples were acquired by monochromatic synchrotron radiation (SR). Due to the narrow beam and a large sample-to-detector distance scattering is rejected in the absorption contrast images (SR-CT). Large contrast enhancement is achieved by the use of the DEI-CT method, where the effects of refraction and scatter rejection are analysed by crystal optics. Clinical mammograms and CT images were recorded as reference material for a radiological examination. Three malignant and benign samples were studied in detail. Their radiographs were compared with optical images of stained histological sections. The DEI-CT images map accurately the morphology of the samples, including collagen strands and micro-calcifications of dimensions less than 0.1 mm. Histo-pathological examination and reading of the radiographs were done independently, and the conclusions were in general agreement. High-resolution DEI-CT images show strong contrast and permit visualization of details invisible in clinical radiographs. The radiation dose may be reduced by an order of magnitude without compromising image quality, which would make possible clinical in vivo DEI-CT with future compact SR sources.
- Subjects :
- Diffraction
Materials science
Image quality
Radiography
media_common.quotation_subject
MESH: Mammography
FIS/07 - FISICA APPLICATA (A BENI CULTURALI, AMBIENTALI, BIOLOGIA E MEDICINA)
Synchrotron radiation
Breast Neoplasms
MESH: Algorithms
[SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine
High-resolution CT, diffraction-enhanced x-ray imaging
Sensitivity and Specificity
[SDV.IB.MN] Life Sciences [q-bio]/Bioengineering/Nuclear medicine
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
X-Ray Diffraction
MESH: Radiographic Image Interpretation, Computer-Assisted
Humans
Contrast (vision)
Radiology, Nuclear Medicine and imaging
media_common
MESH: Humans
[PHYS.PHYS.PHYS-MED-PH] Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph]
Radiological and Ultrasound Technology
business.industry
MESH: X-Ray Diffraction
X-ray
Reproducibility of Results
Refraction
MESH: Sensitivity and Specificity
3. Good health
Radiographic Image Enhancement
MESH: Reproducibility of Results
MESH: Radiographic Image Enhancement
030220 oncology & carcinogenesis
[PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph]
Radiographic Image Interpretation, Computer-Assisted
Female
Monochromatic color
Tomography, X-Ray Computed
MESH: Tomography, X-Ray Computed
Nuclear medicine
business
MESH: Female
Algorithms
MESH: Breast Neoplasms
Mammography
Subjects
Details
- ISSN :
- 13616560 and 00319155
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Physics in Medicine and Biology
- Accession number :
- edsair.doi.dedup.....013b54d42134113cbd93e6e1b18b73a7