DNA Methylation, Stem Cells and Cancer

Authors :: Ligia Gabriela Tataranu
Tiberiu Daianu
Anica Dricu
Daniela Elise Tache
Oana Daianu
Stefana Oana Purcaru
Alice Sandra Buteica
Bogdan Stoleru
Amelia Mihaela Dobrescu
Source :: Methylation-From DNA, RNA and Histones to Diseases and Treatment
Publication Year :: 2012
Publisher :: InTech, 2012.
Abstract: In the past few years ‘cancer stem cells’ (CSCs) area has become an interesting field of cancer research. In 19th century, Durante and Conheim [6] and after one hundred year Sell and Pierce [6, 7] issued the hypothesis that stem cells could induce cancer in all type of tissues. Unlike normal tissue stem cells, cancer stem cells are characterized by an abnormal differen‐ tiation rate, which can lead to tumor [8, 9].