Back to Search
Start Over
Transcatheter Aortic Valve Implantation in Intermediate Surgical Risk Patients With Severe Aortic Stenosis: A Systematic Review and Meta-Analysis
- Source :
- Heart, Lung and Circulation. 27:227-234
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Background: Recent data from randomised and observational studies have reported non-inferior outcomes for transcatheter aortic valve implantation (TAVI) compared to surgical aortic valve replacement (SAVR) in intermediate-risk patients. We performed a systematic review to evaluate the mortality of TAVI compared to SAVR in intermediate-risk patients. Methods: A comprehensive search of four major databases (Embase, Ovid MEDLINE, PubMed, and Google Scholar) was performed from their inception to 29 April 2016. We included original research studies reporting data on TAVI and SAVR in intermediate-risk patients. We compared the outcomes of TAVI to SAVR. Results: A total of 2,375 and 2,377 intermediate-risk patients underwent TAVI and SAVR respectively. The 30-day all-cause (p = 0.07), 30-day cardiac (p = 0.53), and 12-month all-cause mortality (p = 0.34) was similar between the two groups. However, TAVI through transfemoral access had a significantly lower mortality than SAVR (OR 0.58, p = 0.006). The incidence of ≥moderate aortic incompetence (p < 0.00001) and pacemaker implantation (p < 0.0001) was higher in the TAVI group. Conclusions: In the intermediate-risk patients, the 30-day and 12-month mortality are similar between TAVI and SAVR. Increased operator experience and improved device technology have led to a significant reduction in mortality in intermediate-risk patients undergoing TAVI. Refereed/Peer-reviewed
- Subjects :
- Pulmonary and Respiratory Medicine
Aortic valve
medicine.medical_specialty
Cardiac & Cardiovascular Systems
Transcatheter aortic
030204 cardiovascular system & hematology
Global Health
Transcatheter Aortic Valve Replacement
03 medical and health sciences
Postoperative Complications
0302 clinical medicine
Aortic valve replacement
Risk Factors
high-risk
Internal medicine
Humans
Medicine
030212 general & internal medicine
Survival rate
transcatheter aortic valve implantation
intermediate-risk
business.industry
Incidence
Incidence (epidemiology)
Aortic Valve Stenosis
medicine.disease
Surgery
Survival Rate
Stenosis
medicine.anatomical_structure
Aortic Valve
Heart Valve Prosthesis
low-risk
Meta-analysis
Aortic valve stenosis
Cardiology
transcatheter aortic valve replacement
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 14439506
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Heart, Lung and Circulation
- Accession number :
- edsair.doi.dedup.....012640c87ee229d3a2eb0957e23496f9