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Fetal brain during a binge drinking episode: a dynamic susceptibility contrast MRI fetal brain perfusion study
- Source :
- NeuroReport. 21:716-721
- Publication Year :
- 2010
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2010.
-
Abstract
- We assessed the effects of a single episode of maternal alcohol intoxication on fetal brain blood perfusion in three pregnant dams (baboons) at the 24th week of pregnancy using dynamic susceptibility contrast magnetic resonance imaging. After the oral administration of alcohol, there was a four-fold increase in the peak contrast concentrations in the fetal brain. In addition, we observed a two- to three-fold increase in the contrast uptake and washout rates in the fetal brain. The underlying mechanisms of these changes are unknown, but we hypothesized that these could include the alcohol-mediated changes in placental permeability and fetal cerebral blood flow. Our findings indicate that alcohol intoxication produces profound changes, which may detrimentally influence neurodevelopmental processes in the brain.
- Subjects :
- Gadolinium DTPA
medicine.medical_specialty
Time Factors
Perfusion Imaging
Fetal alcohol syndrome
Contrast Media
Binge drinking
Perfusion scanning
Article
Pregnancy
Fetal membrane
Internal medicine
Animals
Medicine
Fetus
Ethanol
medicine.diagnostic_test
business.industry
General Neuroscience
Uterus
Brain
Central Nervous System Depressants
Magnetic resonance imaging
medicine.disease
Magnetic Resonance Imaging
Endocrinology
Cerebral blood flow
Cerebrovascular Circulation
Myometrium
Female
Papio hamadryas
business
Alcoholic Intoxication
Perfusion
Subjects
Details
- ISSN :
- 09594965
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- NeuroReport
- Accession number :
- edsair.doi.dedup.....0125aaa7e3dd8c05ad8373211d46bf3a