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Detection of micrometastatic prostate cancer cells in the bone marrow of patients with prostate cancer
- Source :
- British Journal of Cancer
- Publication Year :
- 1997
- Publisher :
- Springer Science and Business Media LLC, 1997.
-
Abstract
- Thirty-five patients with prostate cancer were examined for micrometastases to the bone marrow using reverse transcription-polymerase chain reaction (RT-PCR) with primers specific for the prostate-specific antigen (PSA) gene. Of nine patients with bone metastases detectable by bone scan imaging, five patients had PSA mRNA expression in the bone marrow detectable by RT-PCR. Of 26 patients with negative bone scan findings, seven patients had PSA mRNA expression detectable in the bone marrow. RT-PCR could detect micrometastatic prostate cancer cells in the bone marrow that were not detectable by bone scan imaging. Of 16 patients with a serum PSA concentration of 25 ng ml(-1) or greater, only nine (56.3%) had bone metastases detected by bone scans. Of the remaining seven patients, five had micrometastases to the bone marrow detected by RT-PCR. Overall, 14 of 16 patients (87.5%) with a serum PSA concentration of 25 ng ml(-1) or greater had metastatic bone diseases including bone marrow micrometastases. Of 19 patients with a serum PSA concentration of less than 25 ng ml(-1), two (10.5%) had only micrometastatic disease detected by RT-PCR. A significant correlation was observed between the incidence of bone involvement and the serum PSA concentration. This study suggests that RT-PCR will potentially develop into a relevant tool to assess bone involvement including bone marrow micrometastases and establish a precise correlation between serum PSA concentration and metastatic bone disease in patients with prostate cancer. Images Figure 1
- Subjects :
- Male
Cancer Research
Pathology
medicine.medical_specialty
Transcription, Genetic
Bone disease
Mrna expression
Bone Neoplasms
Bone scans
Polymerase Chain Reaction
Prostate cancer
Antigen
Bone Marrow
medicine
Humans
In patient
RNA, Messenger
Radionuclide Imaging
business.industry
Prostatic Neoplasms
Prostate-Specific Antigen
medicine.disease
medicine.anatomical_structure
Oncology
Micrometastatic disease
Bone marrow
Bone Marrow Neoplasms
business
Research Article
Subjects
Details
- ISSN :
- 15321827 and 00070920
- Volume :
- 75
- Database :
- OpenAIRE
- Journal :
- British Journal of Cancer
- Accession number :
- edsair.doi.dedup.....01236af3f20adc4dda965da472b2855a