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Circulating Immature and Mature Dendritic Cells in Relation to Lymphocyte Subsets in Patients with Gastrointestinal Tract Cancer
- Source :
- Europe PubMed Central
- Publication Year :
- 2000
- Publisher :
- SAGE Publications, 2000.
-
Abstract
- Cancer-related deficiency in circulating dendritic cells (DC), whose important anticancer role is well established, has been proven to be associated with lymphocytopenia. This study was performed to evaluate which lymphocyte subset is most markedly related to the failure of the DC system. The study included 30 patients with gastrointestinal tract cancer, 10 of whom had distant organ metastases. Immature and mature DCs were measured by FACS and monoclonal antibodies against CD123 and CD11c antigens, respectively. Low levels of immature and mature DCs were observed in 63% and 43% of patients, respectively. Patients with low levels of circulating mature DCs had significantly lower values of T lymphocytes, T helper lymphocytes and NK cells than those with normal mature DC levels. In contrast, no significant difference was seen between patients with normal or abnormally low values of immature DCs. Conversely, patients with a decreased number of T lymphocytes, T helper lymphocytes and NK cells showed significantly lower values of circulating mature DCs than those with lymphocyte subsets within the normal range, whereas no difference was seen in immature DC amounts. This study suggests that only mature DC deficiency may be associated with important lymphocyte subset alterations in cancer patients, whereas deficiency in immature DCs does not seem to be related to other immune cell disorders.
- Subjects :
- CD4-Positive T-Lymphocytes
Male
0301 basic medicine
Interleukin 2
Cancer Research
medicine.drug_class
Lymphocyte
Clinical Biochemistry
Monoclonal antibody
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
Immune system
Antigens, CD
Stomach Neoplasms
T-Lymphocyte Subsets
medicine
Humans
Gastrointestinal Neoplasms
Gastrointestinal tract
business.industry
Dendritic Cells
T-Lymphocytes, Helper-Inducer
Dendritic cell
Middle Aged
medicine.disease
Killer Cells, Natural
030104 developmental biology
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Immunology
Female
Interleukin-3 receptor
Lymphocytopenia
Colorectal Neoplasms
business
Biomarkers
medicine.drug
Subjects
Details
- ISSN :
- 17246008
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- The International Journal of Biological Markers
- Accession number :
- edsair.doi.dedup.....0118e2f20171ced4299ba82d30fa382a