Back to Search
Start Over
Eumitrins C-E: Structurally diverse xanthone dimers from the vietnamese lichen Usnea baileyi
- Source :
- Fitoterapia, Fitoterapia, 2020, 141, pp.104449. ⟨10.1016/j.fitote.2019.104449⟩, Fitoterapia, Elsevier, 2020, 141, pp.104449. ⟨10.1016/j.fitote.2019.104449⟩
- Publication Year :
- 2020
- Publisher :
- HAL CCSD, 2020.
-
Abstract
- International audience; Three new xanthone dimers, eumitrins C - E (1-3), along with a new depsidone, 3'-O-demethylcryptostictinolide (4) were isolated from the acetone extract of the whole thallus of the lichen Usnea baileyi collected in Vietnam. Their structures were unambiguously established by spectroscopic analyses (HRESIMS, 1D and 2D NMR), as well as comparison to literature data. The absolute configurations of 1-3 were elucidated through electronic circular dichroism (ECD) analyses. The absolute configuration of 2 was validated by comparison between experimental and TDDFT-calculated ECD spectra while that of 3 was based on DFT-NMR calculations and subsequent DP4 probability score. The antiparasitic activities against Plasmodium falciparum as well as the cytotoxic activity against seven cell lines were determined for the new compounds 1-3, and led from null to mild bioactivities.
- Subjects :
- Circular dichroism
Magnetic Resonance Spectroscopy
Antiparasitic
medicine.drug_class
Stereochemistry
Xanthones
MESH: Molecular Structure
MESH: Plant Extracts
MESH: Usnea
[CHIM.THER]Chemical Sciences/Medicinal Chemistry
01 natural sciences
MESH: Circular Dichroism
chemistry.chemical_compound
Drug Discovery
Xanthone
medicine
[CHIM]Chemical Sciences
[SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology
Pharmacology
Molecular Structure
Plant Extracts
010405 organic chemistry
Depsidone
MESH: Magnetic Resonance Spectroscopy
Circular Dichroism
MESH: Xanthones
Absolute configuration
General Medicine
Nuclear magnetic resonance spectroscopy
0104 chemical sciences
Thallus
010404 medicinal & biomolecular chemistry
Usnea
Vietnam
chemistry
MESH: Vietnam
Two-dimensional nuclear magnetic resonance spectroscopy
Subjects
Details
- Language :
- English
- ISSN :
- 0367326X and 18736971
- Database :
- OpenAIRE
- Journal :
- Fitoterapia, Fitoterapia, 2020, 141, pp.104449. ⟨10.1016/j.fitote.2019.104449⟩, Fitoterapia, Elsevier, 2020, 141, pp.104449. ⟨10.1016/j.fitote.2019.104449⟩
- Accession number :
- edsair.doi.dedup.....00fe31d00cb06f0b2b0e9432fa219c50