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Genetic Relationship between Methicillin-Sensitive and Methicillin-Resistant Staphylococcus aureus Strains from France and from International Sources: Delineation of Genomic Groups
- Source :
- Journal of Clinical Microbiology. 41:2946-2951
- Publication Year :
- 2003
- Publisher :
- American Society for Microbiology, 2003.
-
Abstract
- Cluster analysis of the Sma I patterns, generated by pulsed-field gel electrophoresis, of 44 methicillin-resistant (MRSA) and 118 methicillin-sensitive (MSSA) Staphylococcus aureus strains isolated in various French hospitals and 61 MRSA and 48 MSSA strains from 20 other countries revealed 20 genomic groups distributed into four distantly related phylogenic branches. Eighty-three of the 105 MRSA strains (79%) were clustered in the six genomic groups of phylogenic branch I; and 154 of the 166 MSSA strains (92.8%) were clustered in the 14 genomic groups of phylogenic branches II, III, and IV. Agreement between genomic group and two other markers, esterase type and phage group, was obtained, emphasizing the clonal structure of the population. The genomic groups were delineated by esterase type. The distribution of the strains within the genomic groups was independent of their geographical origin; French strains were clustered with strains from other countries. The three types of the staphylococcal cassette chromosome mec (SCC mec ) complex were distributed according to genomic groups. Most of the time, type I and type II SCC mec complexes were found in the MRSA strains belonging to the same genomic groups. In contrast, the type III SCC mec complex was specific to the MRSA strains belonging to the three genomic groups characterized by a common esterase type.
- Subjects :
- Microbiology (medical)
Staphylococcus aureus
Meticillin
International Cooperation
Population
Penicillins
Biology
medicine.disease_cause
Staphylococcal infections
Microbiology
SmaI
Methicillin
medicine
Cluster Analysis
Humans
education
Bacteriophage Typing
Phylogeny
Antibacterial agent
Phage typing
Genetics
education.field_of_study
SCCmec
Esterases
Genetic Variation
Bacteriology
Staphylococcal Infections
biochemical phenomena, metabolism, and nutrition
bacterial infections and mycoses
medicine.disease
Methicillin-resistant Staphylococcus aureus
Electrophoresis, Gel, Pulsed-Field
Methicillin Resistance
France
Genome, Bacterial
medicine.drug
Subjects
Details
- ISSN :
- 1098660X and 00951137
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Microbiology
- Accession number :
- edsair.doi.dedup.....00fb519e61120d7fb874ffb3003b10ba