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The Effect of Omega-3 Fatty Acid Supplementation on Serum Adipocytokines, Lipid Profile and Biochemical Markers of Inflammation in Recreational Runners
- Source :
- Nutrients, Volume 13, Issue 2, Zebrowska, A, Hall, B, Stolecka-Warzecha, A, Stanula, A & Sadowska-Krepa, E 2021, ' The Effect of Omega-3 Fatty Acid Supplementation on Serum Adipocytokines, Lipid Profile and Biochemical Markers of Inflammation in Recreational Runners ', Nutrients, vol. 13, no. 2, 456, pp. 1-18 . https://doi.org/10.3390/nu13020456, https://doi.org/10.3390/nu13020456, Nutrients, Vol 13, Iss 456, p 456 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- Background: The study aimed to evaluate the effects of a 3-week ω-3 PUFA supplementation on serum adipocytokines (i.e., adiponectin, leptin), neuregulin-4 (NRG4) and erythrocyte omega-3 (ω-3) fatty acid content, as well as the blood antioxidant defense capacity in non-elite endurance runners. Methods: Twenty-four runners were randomized into two groups: the supplemented group, who received omega free fatty acids extract containing 142 mg of EPA, 267 mg of DHA, 12 mg of vitamin E and 5 µg of vitamin D, each administrated at a dose of six capsules twice a day for three weeks, or the placebo group. Venous blood samples were withdrawn at the start and at the end of the study protocols to estimate serum biochemical variables. Results: A significantly higher ω-3 index and lower AA/EPA ratio was observed after ω-3 PUFA compared to pre-supplementation levels (p &lt<br />0.001 and p &lt<br />0.001, respectively). An increase in baseline adiponectin and NRG4 levels, as well as a decrease of leptin concentration and lipid profile improvement, were observed in subjects after a ω-3 PUFA diet. The increased ω-3 index had a significant effect on TNFα levels and a serum marker of antioxidant defense. Conclusions: The ω-3 PUFA extract with added vitamin E and D supplementation may have a positive effect on the function of the adipocyte tissue, as well as the ability to prevent cardiovascular complications in athletes.
- Subjects :
- 0301 basic medicine
Male
Erythrocytes
medicine.medical_treatment
030204 cardiovascular system & hematology
Running
chemistry.chemical_compound
0302 clinical medicine
physical exercise
Adipocyte
Vitamin E
Adipocytokines
Vitamin D
Neuregulins
chemistry.chemical_classification
Nutrition and Dietetics
medicine.diagnostic_test
Lipids
Cardiovascular Diseases
Inflammation Mediators
lcsh:Nutrition. Foods and food supply
Polyunsaturated fatty acid
Adult
medicine.medical_specialty
Adipokine
lcsh:TX341-641
Article
03 medical and health sciences
Adipokines
Internal medicine
Fatty Acids, Omega-3
medicine
Vitamin D and neurology
Humans
Inflammation
Adiponectin
business.industry
Fatty acid
Physical exercise
Diet
Oxidative Stress
030104 developmental biology
Endocrinology
chemistry
inflammation
adipocytokines
Dietary Supplements
Lipid profile
business
diet
Omega-3 index
Biomarkers
Food Science
omega-3 index
Subjects
Details
- Language :
- English
- ISSN :
- 20726643
- Volume :
- 13
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....00ebb3edde70b29a26679e99f4299224