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Circular RNA circ_0002138 is down-regulated and suppresses cell proliferation in colorectal cancer
- Source :
- Biomedicine & Pharmacotherapy, Vol 111, Iss, Pp 1022-1028 (2019)
- Publication Year :
- 2019
- Publisher :
- Elsevier, 2019.
-
Abstract
- Circular RNAs (circRNAs) have been recently identified as widespread and diverse endogenous noncoding RNAs that may harbor vital functions in humans. However, the role of circRNAs in the process of tumorigenesis and development of colorectal cancer (CRC) remains hitherto vague. In this study, we investigated the expression level of circ_0002138 in 35 paired CRC tissues by quantitative real-time polymerase chain reaction (qRT-PCR) and found that circ_0002138 was stably down-regulated in CRC tissues compared to paired adjacent normal tissues (P
- Subjects :
- 0301 basic medicine
Colorectal cancer
Proliferation
Normal tissue
Down-Regulation
Endogeny
RM1-950
Biology
medicine.disease_cause
law.invention
03 medical and health sciences
0302 clinical medicine
Circular RNA
law
Cell Line, Tumor
Biomarkers, Tumor
medicine
Humans
Polymerase chain reaction
Cell Proliferation
Pharmacology
Cell growth
RNA, Circular
General Medicine
Biomarker
HCT116 Cells
medicine.disease
Biomarker (cell)
CRC
Gene Expression Regulation, Neoplastic
030104 developmental biology
ROC Curve
030220 oncology & carcinogenesis
Cancer research
RNA
Therapeutics. Pharmacology
Colorectal Neoplasms
Carcinogenesis
HT29 Cells
Circ_0002138
Subjects
Details
- Language :
- English
- ISSN :
- 07533322
- Volume :
- 111
- Database :
- OpenAIRE
- Journal :
- Biomedicine & Pharmacotherapy
- Accession number :
- edsair.doi.dedup.....00dc7627fd31c28e0c856d394e2fa2a5