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Preparation, characterization and pharmacokinetics of cyadox nanosuspension
- Source :
- Scientific Reports, Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
- Publication Year :
- 2016
-
Abstract
- An increase in number of newly developed synthetic drugs displays bioavailability constraints because of poor water solubility. Nanosuspensions formulation may help to overwhelm these problems by increasing dissolution velocity and saturation solubility. In the present study, cyadox (Cyx) nanosuspension was successfully prepared by recrystallization based on acid–base neutralization combined with high pressure homogenization method using Polyvinylpyrrolidone K30 (PVP) as stabilizer. The nanosuspension had uniform particle distribution, excellent sedimentation rate and redispersibility. The nanosuspension significantly improved the solubility, dissolution and bioavailability. The saturation solubility of Cyx nanocrystal was higher than that of bulk Cyx and released the total drug in very short time. Further, pharmacokinetics of Cyx nanosuspension and normal suspension following oral administration was investigated in beagle dogs. Nanosuspension improved the bioavailability of Cyx which could be beneficial for intestinal bacterial infection in animals. Maximum concentration and area under concentration time curve were increased with particles size reduction which might give rise to pronounce fluctuations in plasma concentration and more intensified antibacterial effects. The terminal half-life and mean resident time of Cyx nanosuspension had also increased compared to normal Cyx suspension. In conclusion, nanosuspensions may be a suitable delivery approach to increase the bioavailability of poorly soluble drugs.
- Subjects :
- Male
Science
Drug Compounding
Biological Availability
02 engineering and technology
Pharmacology
030226 pharmacology & pharmacy
Article
03 medical and health sciences
0302 clinical medicine
Dogs
Pharmacokinetics
Drug Stability
Suspensions
Oral administration
Quinoxalines
medicine
Animals
Solubility
Particle Size
Dissolution
Multidisciplinary
Aqueous solution
Chromatography
Polyvinylpyrrolidone
Chemistry
Povidone
021001 nanoscience & nanotechnology
Bioavailability
Microscopy, Electron, Scanning
Medicine
Nanoparticles
Female
Particle size
0210 nano-technology
medicine.drug
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 7
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific reports
- Accession number :
- edsair.doi.dedup.....00cb2504102e67f7a9ae26fde459973c