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Feasibility of mapping the tissue mass corrected bioscale of cerebral metabolic rate of oxygen consumption using 17-oxygen and 23-sodium MR imaging in a human brain at 9.4T
- Source :
- NeuroImage. 51:723-733
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- The reduction of molecular oxygen to water is the final step of oxidative phosphorylation that couples adenosine triphosphate production to the reoxidation of reducing equivalents formed during the oxidation of glucose to carbon dioxide. This coupling makes the cerebral metabolic rate of oxygen consumption (CMRO(2)) an excellent reflection of the metabolic health of the brain. A multi-nuclear magnetic resonance (MR) imaging based method for CMRO(2) mapping is proposed. Oxygen consumption is determined by applying a new three-phase metabolic model for water generation and clearance to the changing 17-oxygen ((17)O) labeled water MR signal measured using quantitative (17)O MR imaging during inhalation of (17)O-enriched oxygen gas. These CMRO(2) data are corrected for the regional brain tissue mass computed from quantitative 23-sodium MR imaging of endogenous tissue sodium ions to derive quantitative results of oxygen consumption in micromoles O(2)/g tissue/minute that agree with literature results reported from positron emission tomography. The proposed technique is demonstrated in the human brain using a 9.4 T MR scanner optimized for human brain imaging.
- Subjects :
- Male
Cognitive Neuroscience
Sodium
chemistry.chemical_element
Oxidative phosphorylation
Oxygen
chemistry.chemical_compound
Oxygen Consumption
Nuclear magnetic resonance
Oxygen Radioisotopes
Image Interpretation, Computer-Assisted
medicine
Humans
Radionuclide Imaging
Brain Mapping
medicine.diagnostic_test
Sodium Radioisotopes
business.industry
Brain
Magnetic resonance imaging
Human brain
Middle Aged
Magnetic Resonance Imaging
medicine.anatomical_structure
Neurology
chemistry
Positron emission tomography
Carbon dioxide
Feasibility Studies
Radiopharmaceuticals
Nuclear medicine
business
Subjects
Details
- ISSN :
- 10538119
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- NeuroImage
- Accession number :
- edsair.doi.dedup.....00c949b61c7cd8aa4807803d9accc7f7