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Hemodynamic Parameters in the Parent Arteries of Unruptured Intracranial Aneurysms Depend on Aneurysm Size and Are Different Compared to Contralateral Arteries: A 7 Tesla <scp>4D</scp> Flow <scp>MRI</scp> Study

Authors :
Rick J. van Tuijl
Kimberley M. Timmins
Birgitta K. Velthuis
Pim van Ooij
Jaco J.M. Zwanenburg
Ynte M. Ruigrok
Irene C. van der Schaaf
Radiology and Nuclear Medicine
ACS - Atherosclerosis & ischemic syndromes
ACS - Heart failure & arrhythmias
AMS - Ageing & Vitality
AMS - Sports
Source :
Journal of magnetic resonance imaging. John Wiley and Sons Inc.
Publication Year :
2023
Publisher :
Wiley, 2023.

Abstract

Background: Different Circle of Willis (CoW) variants have variable prevalences of aneurysm development, but the hemodynamic variation along the CoW and its relation to presence and size of unruptured intracranial aneurysms (UIAs) are not well known. Purpose: Gain insight into hemodynamic imaging markers of the CoW for UIA development by comparing these outcomes to the corresponding contralateral artery without an UIA using 4D flow magnetic resonance imaging (MRI). Study Type: Retrospective, cross-sectional study. Subjects: Thirty-eight patients with an UIA, whereby 27 were women and a mean age of 62 years old. Field Strength/Sequence: Four-dimensional phase-contrast (PC) MRI with a 3D time-resolved velocity encoded gradient echo sequence at 7 T. Assessment: Hemodynamic parameters (blood flow, velocity pulsatility index [vPI], mean velocity, distensibility, and wall shear stress [peak systolic (WSSMAX), and time-averaged (WSSMEAN)]) in the parent artery of the UIA were compared to the corresponding contralateral artery without an UIA and were related to UIA size. Statistical Tests: Paired t-tests and Pearson Correlation tests. The threshold for statistical significance was P &lt; 0.05 (two-tailed). Results: Blood flow, mean velocity, WSSMAX, and WSSMEAN were significantly higher, while vPI was lower, in the parent artery relative to contralateral artery. The WSSMAX of the parent artery significantly increased linearly while the WSSMEAN decreased linearly with increasing UIA size. Conclusions: Hemodynamic parameters and WSS differ between parent vessels of UIAs and corresponding contralateral vessels. WSS correlates with UIA size, supporting a potential hemodynamic role in aneurysm pathology. Level of Evidence: 2. Technical Efficacy: Stage 2.

Details

ISSN :
15222586 and 10531807
Database :
OpenAIRE
Journal :
Journal of Magnetic Resonance Imaging
Accession number :
edsair.doi.dedup.....00c784cf4304a880a176e92cf26cc1a1
Full Text :
https://doi.org/10.1002/jmri.28756