Back to Search
Start Over
GAP-43 Immunoreactivity in the brain of the developing and adult wallaby ( Macropus eugenii)
- Source :
- Anatomy and embryology. 206(1-2)
- Publication Year :
- 2002
-
Abstract
- We have examined the distribution of immunoreactivity for GAP-43 in the developing and adult brain of a diprotodontid metatherian, the tammar wallaby ( Macropus eugenii). The distribution of GAP-43 immunoreactivity in the neonatal wallaby brain was strikingly heterogeneous, in contrast to that reported for the newborn polyprotodontid opossum. Immunoreactivity for GAP-43 in the developing wallaby brain showed a caudal-to-rostral spatiotemporal gradient, with the brainstem well in advance of the telencephalon throughout the first 100 days of postnatal life. In many regions examined, GAP-43 immunoreactivity passed through the following phases: 1. intense immunoreactivity in developing fiber tracts and occasional somata; 2. diffuse homogeneous immunoreactivity; 3. selective loss of immunoreactivity in particular nuclei or cortical regions. In the isocortex, selective loss of GAP-43 immunoreactivity in the somatosensory and visual cortex (at postnatal day 115) coincided with the maturation of the laminar distribution of terminal thalamocortical axonal fields. Within adult cortical regions, GAP-43 immunoreactivity was highest in layer I of all regions, lower layers (V and VI) of primary somatosensory and visual cortices, layers II/III of motor and cingulate cortex, and layer IV of entorhinal cortex. Our findings suggest that, while patterning of GAP-43 immunoreactivity in the mature brain is similar across meta- and eutheria, there may be early developmental differences in the distribution of GAP-43 immunoreactivity between poly- and diprotodontid metatheria.
- Subjects :
- Olfactory system
Embryology
Tammar wallaby
GAP-43 Protein
Species Specificity
Opossum
medicine
Animals
Humans
Macropus
Marsupial
Macropodidae
biology
Cerebrum
Brain
Cell Biology
Anatomy
Opossums
biology.organism_classification
Entorhinal cortex
Immunohistochemistry
Olfactory Bulb
Rats
medicine.anatomical_structure
Animals, Newborn
Brainstem
Developmental Biology
Subjects
Details
- ISSN :
- 03402061
- Volume :
- 206
- Issue :
- 1-2
- Database :
- OpenAIRE
- Journal :
- Anatomy and embryology
- Accession number :
- edsair.doi.dedup.....00be3c606e3d0b8fd5bfabd041c82a4f