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SUMOylation in Glioblastoma: A Novel Therapeutic Target
- Source :
- International Journal of Molecular Sciences, Vol 20, Iss 8, p 1853 (2019), International Journal of Molecular Sciences
- Publication Year :
- 2019
- Publisher :
- MDPI AG, 2019.
-
Abstract
- Protein SUMOylation is a dynamic post-translational modification which is involved in a diverse set of physiologic processes throughout the cell. Of note, SUMOylation also plays a role in the pathobiology of a myriad of cancers, one of which is glioblastoma (GBM). Accordingly, herein, we review core aspects of SUMOylation as it relates to GBM and in so doing highlight putative methods/modalities capable of therapeutically engaging the pathway for treatment of this deadly neoplasm.
- Subjects :
- Protein sumoylation
Cell
SUMO protein
Antineoplastic Agents
Review
Biology
Catalysis
lcsh:Chemistry
Inorganic Chemistry
medicine
Animals
Humans
ddc:610
Molecular Targeted Therapy
Sumo1-3
Physical and Theoretical Chemistry
lcsh:QH301-705.5
Molecular Biology
Protein Processing
Spectroscopy
Glioblastoma (gbm)
Brain Neoplasms
Organic Chemistry
Post-Translational
Sumoylation
Brain
General Medicine
medicine.disease
nervous system diseases
Computer Science Applications
Post-translational modifications (ptms)
medicine.anatomical_structure
lcsh:Biology (General)
lcsh:QD1-999
Glioblastoma
Protein Processing, Post-Translational
Small Ubiquitin-Related Modifier Proteins
Cancer research
Subjects
Details
- ISSN :
- 14220067
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....00af78774aa0e72d01211b469879bd9e