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Vomeronasal Epithelial Cells of Human Fetuses Contain Immunoreactivity for G Proteins, Goalpha and Gialpha2
- Source :
- Chemical Senses. 26:517-522
- Publication Year :
- 2001
- Publisher :
- Oxford University Press (OUP), 2001.
-
Abstract
- Two G protein subfamilies, Go(alpha) and Gi(alpha 2), were identified and localized immunohistochemically in the vomeronasal organ (VNO) of 5-month-old human fetuses. Immunoreactivity for Go(alpha) and Gi(alpha 2) was present in a subset of vomeronasal epithelial cells. Prominent immunoreactivity was observed in apical processes and their apical terminals facing onto the vomeronasal lumen. Nerve fibers associated with the VNO exhibited intense immunoreactivity for Go(alpha) and weak immunoreactivity for Gi(alpha 2). Since Go(alpha) and Gi(alpha 2) are characteristically expressed and coupled with putative pheromone receptors in rodent vomeronasal receptor neurons, the present results suggest the possibility that vomeronasal epithelial cells containing Go(alpha) and Gi(alpha 2) in human fetuses are chemosensory neurons.
- Subjects :
- medicine.medical_specialty
Vomeronasal organ
Physiology
G protein
GTP-Binding Protein alpha Subunits
Alpha (ethology)
GTP-Binding Protein alpha Subunits, Gi-Go
Biology
Rats, Sprague-Dawley
Behavioral Neuroscience
Vomeronasal receptor
GTP-Binding Proteins
Physiology (medical)
Internal medicine
medicine
Animals
Humans
Neurons, Afferent
Receptor
Epithelial Cells
Heterotrimeric GTP-Binding Proteins
Immunohistochemistry
Molecular biology
Chemoreceptor Cells
Sensory Systems
Sensory neuron
Rats
Endocrinology
medicine.anatomical_structure
Pheromone
Vomeronasal Organ
Subjects
Details
- ISSN :
- 14643553
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Chemical Senses
- Accession number :
- edsair.doi.dedup.....00a3f5621cf4404d0ec005c0d79dd978