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Interactions of neuromuscular effects of edrophonium, alpha-bungarotoxin and beta-bungarotoxin
- Source :
- Anesthesiology. 48(5)
- Publication Year :
- 1978
-
Abstract
- Interactions of neuromuscular effects of edrophonium, alpha-bungarotoxin, and beta-bungarotoxin were studied in 12 chickens using the sciatic-gastrocnemius nerve-muscle preparation to elucidate the mechanism of action of each drug. Modification by the toxins of neuromuscular effects of edrophonium depended on the level of block pre-established by the toxins. Edrophonium-induced augmentation of muscle twitch ("facilitation") was decreased by both toxins. As the block reached 50 per cent, the facilitation was nearly abolished. Edrophonium-induced contracture of the muscle was blocked by alpha-bungarotoxin only. At 25 per cent block, it was no longer observable in five of six preparations. Beta-bungarotoxin enhanced the contracture. At complete block, the contracture reached 156 (SE 11, n = 6) per cent of control. The authors conclude that edrophonium facilitates neuromuscular transmission by a prejunctional mechanism and causes contracture of the chicken muscle by a post-junctional activation. The beta-bungarotoxin-blocked nerve-muscle preparation of the chicken is a model of acute denervation potentially useful for the study of drug effects on the postjunctional membrane.
- Subjects :
- animal structures
Models, Neurological
Neuromuscular transmission
Neuromuscular Junction
Edrophonium
Pharmacology
Synaptic Transmission
chemistry.chemical_compound
Medicine
Animals
Drug Interactions
Denervation
business.industry
Neuromuscular Effects
Alpha-Bungarotoxin
Bungarotoxins
Anesthesiology and Pain Medicine
chemistry
Mechanism of action
beta-bungarotoxin
Female
Contracture
medicine.symptom
business
Chickens
medicine.drug
Muscle Contraction
Subjects
Details
- ISSN :
- 00033022
- Volume :
- 48
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Anesthesiology
- Accession number :
- edsair.doi.dedup.....00a2d086c1e0f680d1a1e983e6cb8864