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NUDT15 is a key genetic factor for prediction of hematotoxicity in pediatric patients who received a standard low dosage regimen of 6-mercaptopurine
- Source :
- Drug metabolism and pharmacokinetics. 43
- Publication Year :
- 2021
-
Abstract
- 6-Mercaptopurine (6-MP) is commonly used for treatment of acute lymphoblastic leukemia (ALL). The incidence of hematotoxicity caused by this drug is quite high in Asians even using a standard low dosage regimen. The present study was aimed to elucidate the impact of thiopurine S-methyltransferase (TPMT), a nucleoside diphosphate-linked moiety X-type motif 15 (NUDT15), inosine triphosphatase (ITPA) and ATP Binding Cassette Subfamily C Member 4 (ABCC4) polymorphisms on hematotoxicity in pediatric patients who received a standard low starting dose of 6-MP. One hundred and sixty-nine pediatric patients were enrolled and their genotypes were determined. Patients who carried NUDT15
Details
- ISSN :
- 18800920
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- Drug metabolism and pharmacokinetics
- Accession number :
- edsair.doi.dedup.....00a19ab6d4e9ce059efc8992ca67f96c