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Retained Activity of an O25b-Specific Monoclonal Antibody against an Mcr-1-Producing Escherichia coli Sequence Type 131 Strain
- Source :
- Antimicrobial Agents and Chemotherapy
- Publication Year :
- 2018
- Publisher :
- American Society for Microbiology, 2018.
-
Abstract
- Plasmid-encoded colistin resistance is emerging among extraintestinal pathogenic Escherichia coli strains, including those of the epidemic clone sequence type 131 (ST131)-H30. Mcr-1 transfers a phosphoethanolamine to the lipid A portion of lipopolysaccharide (LPS), conferring resistance to polymyxins. We investigated whether this modification changed the activity of the monoclonal antibody ASN-4, specific to the O25b side chain of ST131 LPS. We confirmed that, unlike colistin, ASN-4 retained its bactericidal and endotoxin-neutralizing activities and therefore offers a treatment option against extremely drug-resistant ST131 isolates.
- Subjects :
- Lipopolysaccharides
0301 basic medicine
Extraintestinal Pathogenic Escherichia coli
medicine.drug_class
Polymyxin
030106 microbiology
Clone (cell biology)
mcr-1
Monoclonal antibody
medicine.disease_cause
Microbiology
Lipid A
Mice
03 medical and health sciences
Drug Resistance, Multiple, Bacterial
medicine
Animals
Humans
Experimental Therapeutics
Pharmacology (medical)
Escherichia coli
Escherichia coli Infections
Pharmacology
Mice, Inbred BALB C
Colistin
Chemistry
Escherichia coli Proteins
Antibodies, Monoclonal
Escherichia coli ST131
Anti-Bacterial Agents
Endotoxins
Infectious Diseases
Female
lipids (amino acids, peptides, and proteins)
MCR-1
monoclonal antibodies
medicine.drug
Subjects
Details
- ISSN :
- 10986596 and 00664804
- Volume :
- 62
- Database :
- OpenAIRE
- Journal :
- Antimicrobial Agents and Chemotherapy
- Accession number :
- edsair.doi.dedup.....009019a41d2682e7eace7442f8daab73