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A comparison of the potency of trimedoxime and other currently available oximes to reactivate tabun-inhibited acetylcholinesterase and eliminate acute toxic effects of tabun
- Source :
- Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. 149(2)
- Publication Year :
- 2006
-
Abstract
- Tabun (O-ethyl-N,N-dimethyl phosphoramidocyanidate) belongs to highly toxic organophosphorus compounds misused as chemical warfare agents for military as well as terroristic purposes. It differs from other highly toxic organophosphates by its chemical structure and by the fact that tabun-inhibited acetylcholinesterase is extraordinarily difficult to reactivate. The potency of trimedoxime and other commonly used oximes (pralidoxime, obidoxime, the oxime HI-6) to reactivate tabun-inhibited acetylcholinesterase and to eliminate tabun-induced acute effects was evaluated using in vitro and in vivo methods. In vitro calculated kinetic parameters of reactivation of tabun-inhibited acetylcholinesterase from rat brain homogenate and in vivo determined percentage of reactivation of tabun-inhibited blood and tissue acetylcholinesterase in poisoned rats show that trimedoxime seems to be the most efficacious reactivator in the case of tabun poisonings. Trimedoxime was also found to be the most efficacious oxime in the elimination of acute lethal toxic effects in tabun-poisoned rats and mice. The oxime HI-6, so efficacious against soman, does not seem to be sufficiently effective oxime to reactivate tabun-inhibited acetylcholinesterase and to counteract acute lethal effects of tabun.
- Subjects :
- Obidoxime
Male
Cholinesterase Reactivators
Pralidoxime
Mice, Inbred Strains
Pharmacology
In Vitro Techniques
General Biochemistry, Genetics and Molecular Biology
chemistry.chemical_compound
Mice
In vivo
Soman
Oximes
medicine
Animals
Trimedoxime
Chemical Warfare Agents
Rats, Wistar
Tabun
Brain
Oxime
Acetylcholinesterase
Organophosphates
Rats
chemistry
Cholinesterase Inhibitors
medicine.drug
Subjects
Details
- ISSN :
- 12138118
- Volume :
- 149
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia
- Accession number :
- edsair.doi.dedup.....0083a9fe4c4aff5b8906ad36dfbbf16d