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Strong Prognostic Value of Microsatellite Instability in Intestinal Type Non-cardia Gastric Cancer
- Source :
- Annals of surgical oncology. 23(3)
- Publication Year :
- 2015
-
Abstract
- The clinical role of microsatellite instability (MSI) in gastric cancer (GC) is controversial. A large series of patients submitted to respective surgery for primary GC with a long follow-up time was evaluated. 472 patients with prospectively collected frozen samples of normal mucosa and tumor tissue stored in a biological tissue bank were included. Microsatellite analysis was evaluated using 5 quasi monomorphic mononucleotide repeats (BAT-26, BAT-25, NR-24, NR-21, and NR-27). The presence of MSI in 2 or more loci was classified as MSI-H, whereas all other cases were included in the microsatellite-stable (MSS) group. MSI-H phenotype was found in 111 of 472 patients (23.5 %). MSI-H status was related significantly with older age, female gender, non-cardia location, WHO histotype, non-cardia Lauren intestinal type, and less advanced stages. Cancer-related 5-year survival was significantly higher in MSI-H versus MSS group (67.6 % vs. 35 %, p
- Subjects :
- 0301 basic medicine
Male
Bioinformatics
Gastroenterology
Polymerase Chain Reaction
0302 clinical medicine
Prospective Studies
Hazard ratio
Cardia
Lauren histotype
Prognosis
Lynch syndrome
Survival Rate
Phenotype
Oncology
030220 oncology & carcinogenesis
Lymphatic Metastasis
Female
Microsatellite Instability
medicine.medical_specialty
Adenocarcinoma
Microsatellite instability, gastric cancer, prognosis, Lauren histotype
03 medical and health sciences
Gastrectomy
Stomach Neoplasms
Internal medicine
Intestinal Neoplasms
medicine
Carcinoma
Humans
Neoplasm Invasiveness
neoplasms
Survival rate
Aged
Neoplasm Staging
Proportional hazards model
business.industry
gastric cancer
Case-control study
Microsatellite instability
Cancer
medicine.disease
digestive system diseases
Carcinoma, Papillary
030104 developmental biology
Case-Control Studies
Lymph Node Excision
Surgery
business
Carcinoma, Signet Ring Cell
Follow-Up Studies
Subjects
Details
- ISSN :
- 15344681
- Volume :
- 23
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Annals of surgical oncology
- Accession number :
- edsair.doi.dedup.....007f0b7e495b37087f7cc78887f80ec4