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Complete Metabolic Response Assessed by FDG PET/CT to FOLFOXIRI-Bevacizumab in First-Line Treatment of BRAFV600E Mutated Metastatic Colorectal Cancer
- Source :
- Clinical Nuclear Medicine. 45:707-708
- Publication Year :
- 2020
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2020.
-
Abstract
- Triplet chemotherapy (FOLFOXIRI) + bevacizumab regimen is indicated as first-line treatment of BRAF-mutated metastatic colorectal cancer (mCRC). Nevertheless, its proven therapeutic efficacy in clinical trials was solely based on partial morphologic responses assessed by CT. To date, only 1 case of complete response assessed by FDG PET/CT was reported in literature in BRAF-mutated mCRC, but treated with doublet chemotherapy (FOLFIRI) + cetuximab regimen. We report a complete metabolic response assessed by FDG PET/CT, maintained over time (13 months) in a 60-year-old woman with BRAF-mutated mCRC treated by FOLFOXIRI-bevacizumab. This also confirms that FDG PET/CT is emerging as a useful approach for therapeutic assessment of targeted drugs in mCRC.
- Subjects :
- Proto-Oncogene Proteins B-raf
Oncology
medicine.medical_specialty
Organoplatinum Compounds
Bevacizumab
Colorectal cancer
medicine.medical_treatment
Leucovorin
Cetuximab
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Fluorodeoxyglucose F18
Positron Emission Tomography Computed Tomography
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Radiology, Nuclear Medicine and imaging
Neoplasm Metastasis
neoplasms
Chemotherapy
FOLFOXIRI
business.industry
General Medicine
Middle Aged
medicine.disease
digestive system diseases
Clinical trial
Regimen
Treatment Outcome
030220 oncology & carcinogenesis
Mutation
FOLFIRI
Camptothecin
Female
Fluorouracil
Colorectal Neoplasms
business
medicine.drug
Subjects
Details
- ISSN :
- 15360229 and 03639762
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- Clinical Nuclear Medicine
- Accession number :
- edsair.doi.dedup.....00793bbd472f61520695b5cf4e0fd1b2