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Cytokines correlate with age in healthy volunteers, dialysis patients and kidney-transplant patients
- Source :
- Cytokine, Cytokine, Elsevier, 2009, 45 (3), pp.169-173. ⟨10.1016/j.cyto.2008.11.014⟩, Cytokine, 2009, 45 (3), pp.169-73. ⟨10.1016/j.cyto.2008.11.014⟩, Cytokine / Cytokines, Cytokine / Cytokines, 2009, 45 (3), pp.169-73. ⟨10.1016/j.cyto.2008.11.014⟩
- Publication Year :
- 2009
- Publisher :
- HAL CCSD, 2009.
-
Abstract
- International audience; T-cell functions are currently used as biomarkers for the pharmacodynamic monitoring of immunosuppressive drugs or as disease biomarkers of inflammation/sepsis and organ rejection. In order to evaluate co-factors potentially influencing the expression of the immunological biomarkers, we explored T-cell proliferation, T-cell activation (CD25 and CD71 expressions) and intra-lymphocyte cytokine production (interleukin (IL)-2 and tumor necrosis factor (TNF)-alpha) in healthy volunteers, dialysis patients and stable kidney-transplant patients treated with standard immunosuppressive therapy, i.e. tacrolimus, mycophenolic acid with or without steroids. Age was positively correlated with TNF-alpha expression in all three patient populations, and with IL-2 expression in healthy volunteers and kidney-transplant patients. Further age was correlated with inhibition of lymphocyte proliferation in healthy volunteers and with the T-cell activation marker CD25 in kidney-transplant patients. In healthy volunteers lymphocyte proliferation was higher in woman as compared to men. Other biomarkers of T-cell function were independent of the gender. In the kidney-transplant patient group a significantly lower expression of all biomarkers of T-cell functions compared to healthy volunteers and dialysis patients. In dialysis patients we found significant increased IL-2 expression compared to healthy volunteers, while the other T-cell functions were not significantly different. Further time on dialysis had no effect on the level of biomarker expression. In conclusion we found decreased T-cell functions in kidney-transplant patients compared to healthy volunteers and dialysis patients, increased IL-2 expression in dialysis patients compared to healthy volunteers and in all three populations we found a correlation of age and intra-T-lymphocyte TNF-alpha expression.
- Subjects :
- Male
Aging
T-Lymphocytes
medicine.medical_treatment
[SDV]Life Sciences [q-bio]
MESH: Interleukin-2 Receptor alpha Subunit
030232 urology & nephrology
Lymphocyte proliferation
030204 cardiovascular system & hematology
Biochemistry
Gastroenterology
MESH: Kidney Transplantation
0302 clinical medicine
Immunology and Allergy
MESH: Aging
MESH: Renal Dialysis
MESH: Antigens, CD
ComputingMilieux_MISCELLANEOUS
MESH: Cytokines
MESH: Middle Aged
Hematology
Middle Aged
3. Good health
Cytokine
Cytokines
Biomarker (medicine)
Female
medicine.drug
Adult
medicine.medical_specialty
Immunology
Mycophenolic acid
Sepsis
03 medical and health sciences
Antigens, CD
Renal Dialysis
Internal medicine
MESH: Cell Proliferation
Receptors, Transferrin
medicine
Humans
MESH: Receptors, Transferrin
Molecular Biology
Dialysis
Cell Proliferation
MESH: Humans
Tumor Necrosis Factor-alpha
business.industry
Interleukin-2 Receptor alpha Subunit
MESH: Biological Markers
MESH: Adult
MESH: Interleukin-2
medicine.disease
Kidney Transplantation
Tacrolimus
MESH: Male
Transplantation
MESH: T-Lymphocytes
MESH: Tumor Necrosis Factor-alpha
Interleukin-2
business
MESH: Female
Biomarkers
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Subjects
Details
- Language :
- English
- ISSN :
- 10434666 and 10960023
- Database :
- OpenAIRE
- Journal :
- Cytokine, Cytokine, Elsevier, 2009, 45 (3), pp.169-173. ⟨10.1016/j.cyto.2008.11.014⟩, Cytokine, 2009, 45 (3), pp.169-73. ⟨10.1016/j.cyto.2008.11.014⟩, Cytokine / Cytokines, Cytokine / Cytokines, 2009, 45 (3), pp.169-73. ⟨10.1016/j.cyto.2008.11.014⟩
- Accession number :
- edsair.doi.dedup.....00786a6fa6660f75107910806c82bb76