Back to Search
Start Over
Role of erythropoietin and its receptor in the development of endometriosis in rats
- Source :
- Journal of the Turkish-German Gynecological Association, Vol 20, Iss 1, Pp 41-46 (2019), Journal of the Turkish German Gynecological Association
- Publication Year :
- 2018
- Publisher :
- Galenos Yayinevi, 2018.
-
Abstract
- Objective: Besides its hematopoietic function, erythropoietin (EPO) may protect tissues from degenerative disorders. As such, EPO and its receptors were revealed in nonhematopoietic cells, including stromal and endometrial epithelial cells. However, the role of EPO in endometrial disorders is still unknown. Here, we aimed to examine the role of EPO and its receptor activation in the development of endometriosis in rats. Material and Methods: Animals were treated with EPO, darbepoietin (the synthetic form of EPO) or EPO’s receptor activator, methoxy polyethylene glycol-epoetin beta (MIRCERA), after development of endometriosis. Endometriosis was induced by estrogen-administration following surgical attachment of endometrial surface on the inner abdominal wall. Treatments were started 3 weeks after induction of endometriosis and continued for the following 3 weeks. For the analysis of recurrence of endometriosis, additional analyses were conducted 3 weeks after cessation of treatments. Results: As compared with vehicle-treated animals, lesion size was reduced significantly and recurrence of endometriosis was not observed in all treatment groups. Histopathologic examination revealed that EPO and darbepoietin were more effective than MIRCERA- and vehicle-treated animals. Conclusion: Here we provide evidence that EPO is a promising candidate for the treatment of endometriosis. Our histopathologic results in particular indicate that EPO is more effective than its receptor activator MIRCERA in the development endometriosis. © 2019 by the Turkish-German Gynecological Education and Research Foundation. Türkiye Bilimler Akademisi Acknowledgements: This work was funded by Turkish Academy of Sciences (TUBA). We would like to thank to Laboratory Technician Nurhayat Dönek from Bezmialem University for help throughout this research.
- Subjects :
- endometriosis
medicine.medical_specialty
Stromal cell
mircera
Endometriosis
lcsh:Medicine
lcsh:Gynecology and obstetrics
Receptor activator
Lesion
Abdominal wall
03 medical and health sciences
0302 clinical medicine
Internal medicine
hemic and lymphatic diseases
medicine
MIRCERA
Receptor
Erythropoietin
lcsh:RG1-991
Original Investigation
Activator (genetics)
business.industry
lcsh:R
receptor activator
Obstetrics and Gynecology
medicine.disease
Darbepoietin
Haematopoiesis
Endocrinology
medicine.anatomical_structure
darbepoietin
erythropoietin
medicine.symptom
business
030215 immunology
medicine.drug
Subjects
Details
- ISSN :
- 13090399
- Database :
- OpenAIRE
- Journal :
- Journal of the Turkish-German Gynecological Association
- Accession number :
- edsair.doi.dedup.....006e00867d74f9034869cf473bf9e64c